Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson’s disease.

Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson’s disease.

Publication date: Jun 10, 2019

Introduction: Cognitive impairment is a common symptom of Parkinson’s disease (PD) associated with reduced quality of life and a more severe disease state. Previous research has shown an association between visuospatial dysfunction and worse disease course; however, it is not clear whether this is separable from executive dysfunction and/or dementia. This study sought to determine whether distinct cognitive factors could be measured in a large PD cohort, and if those factors were differentially associated with other PD-related features, specifically to provide insight into visuospatial dysfunction. Methods: Non-demented participants with PD from the Pacific Udall Center were enrolled (n = 197). Co-participants (n = 104) completed questionnaires when available. Principal components factor analysis (PCFA) was utilized to group the neuropsychological test scores into independent factors by considering those with big factor loading (≥.40). Linear and logistic regression analyses were performed to examine the relationship between the cognitive factors identified in the PCFA and other clinical features of PD. Results: Six factors were extracted from the PCFA: 1) executive/processing speed, 2) visual learning & memory/visuospatial, 3) auditory working memory, 4) contextual verbal memory, 5) semantic learning & memory, and 6) visuospatial. Motor severity (p = 0.001), mood (p

Specketer, K., Zabetian, C.P., Edwards, K.L., Tian, L., Quinn, J.F., Peterson-Hiller, A.L., Chung, K.A., Hu, S.C., Montine, T.J., and Cholerton, B.A. Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson’s disease. 21114. 2019 J Clin Exp Neuropsychol.

Concepts Keywords
Auditory Sleep disturbance hallucinations
Cognitive Dementia
Cognitive Impairment Neuropsychology
Cohort Neuroscience
Dementia Cognitive science
Factor Loading Neuropsychological assessment
Hallucinations Cognition
Logistic Regression Neuropsychological tests
Memory Cognitive disorders
Neuropsychological Test Executive dysfunction
Parkinson Visuospatial function
Semantic Parkinson’s disease
Separable Cognitive deficit
Sleep Disturbance Working memory
Symptom
Visuospatial
Working Memory

Semantics

Type Source Name
pathway BSID Aging
disease MESH Aging
gene UNIPROT LARGE1
disease DOID dementia
disease MESH dementia
disease MESH Cognitive impairment
disease MESH hallucinations

Original Article

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