Publication date: Jun 10, 2019
Introduction: Cognitive impairment is a common symptom of Parkinson’s disease (PD) associated with reduced quality of life and a more severe disease state. Previous research has shown an association between visuospatial dysfunction and worse disease course; however, it is not clear whether this is separable from executive dysfunction and/or dementia. This study sought to determine whether distinct cognitive factors could be measured in a large PD cohort, and if those factors were differentially associated with other PD-related features, specifically to provide insight into visuospatial dysfunction. Methods: Non-demented participants with PD from the Pacific Udall Center were enrolled (n = 197). Co-participants (n = 104) completed questionnaires when available. Principal components factor analysis (PCFA) was utilized to group the neuropsychological test scores into independent factors by considering those with big factor loading (≥.40). Linear and logistic regression analyses were performed to examine the relationship between the cognitive factors identified in the PCFA and other clinical features of PD. Results: Six factors were extracted from the PCFA: 1) executive/processing speed, 2) visual learning & memory/visuospatial, 3) auditory working memory, 4) contextual verbal memory, 5) semantic learning & memory, and 6) visuospatial. Motor severity (p = 0.001), mood (p
Specketer, K., Zabetian, C.P., Edwards, K.L., Tian, L., Quinn, J.F., Peterson-Hiller, A.L., Chung, K.A., Hu, S.C., Montine, T.J., and Cholerton, B.A. Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson’s disease. 21114. 2019 J Clin Exp Neuropsychol.