Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease

Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease

Publication date: Jun 10, 2019

This is a double-blind, placebo-controlled 2-period 10-week treatment within-subject crossover study of neflamapimod in early-stage Huntington disease (HD). The primary objective is to determine whether neflamapimod can reverse hippocampal dysfunction in patients with early-stage HD, as assessed by the virtual water-maze-test for evaluating spatial learning and selected tests on the Cambridge Neuropsychological Test Automated Battery (CANTAB).

Concepts Keywords
Alanine Aminotransferase Neurosurgery
Alcohol Contraception requirements protocol
Allergy Alpha
ALT Cognitive test
Anemia Suicidal ideation
Aspartate Aminotransferase Dementia
AST Cognitive disorders
Auditory Learning disabilities
Bilirubin Human behavior
Blood Pressure Psychiatric diagnosis
Brain RTT
Breast Feeding Psychological testing
Cardiovascular Articles
Central Nervous System Psychology
Cognitive Hysterectomy
Concurrent Neurosurgery
Congestive Heart Failure Contraception
Contraception Dysfunction
Contraceptive Necrosis
Crossover Metabolic endocrine disorders
Cytochrome P450 Myocardial infarction
Dementia Tumor
Diastolic Contraceptive requirements protocol
Double Blind Active psychiatric disorder
Drug Abuse Contraception requirements protocol
Electrolyte Abnormalities Contraceptive requirements protocol
Endocrine Disorders
Hemoglobin
Hepatitis
Hippocampal
Huntington
Hypertension
Hysterectomy
Immune Disorder
Immunodeficiency
Infection
Infectious Disease
Informed Consent
Inhibitor
INR
International Normalized Ratio
Investigational Drug
Learning Difficulties
Lewy Bodies
Liver
MAP Kinase
Maze
Menopause
Mitogen
MmHg
Myocardial Infarction
Neurosurgery
Oophorectomy
P38
Parkinson
Period 10
Placebo
Protocol
Psychiatric Disorder
Pulmonary
Renal
Spatial Learning
Suicidal Thoughts
Suicide
Systolic
Thyroid
Vascular Dementia
Virtual Water
Virus

Semantics

Type Source Name
gene UNIPROT ALG3
gene UNIPROT NR4A2
disease DOID allergy
disease MESH allergy
gene UNIPROT PPIG
disease MESH latent tuberculosis
disease DOID virus infection
disease MESH virus infection
pathway BSID Hepatitis C
disease DOID hepatitis C
disease DOID vascular dementia
disease MESH vascular dementia
disease MESH Diagnosis
gene UNIPROT ELL
disease MESH Men
drug DRUGBANK Water
drug DRUGBANK Neflamapimod
disease MESH Huntington Disease
disease DOID Huntington Disease
disease MESH hepatitis C
pathway BSID Hepatitis B
disease DOID hepatitis B
disease MESH hepatitis B
drug DRUGBANK L-Alanine
gene UNIPROT SLC17A5
disease MESH abnormalities
disease DOID Anemia
disease MESH Anemia
gene UNIPROT SGSM3
gene UNIPROT CRK
gene UNIPROT MAPK1
gene UNIPROT AHSA1
gene UNIPROT GRAP2
gene UNIPROT POLDIP2
gene UNIPROT MAPK14
gene UNIPROT AIMP2
disease MESH immune disorder
pathway BSID Infectious disease
disease DOID infectious disease
disease MESH infectious disease
disease MESH renal
disease DOID congestive heart failure
disease MESH congestive heart failure
disease DOID myocardial infarction
disease MESH myocardial infarction
disease DOID hypertension
disease MESH hypertension
disease MESH drug abuse
drug DRUGBANK Ethanol
disease MESH depressive symptoms
disease MESH Suicide
gene UNIPROT YES1
disease DOID dementia with Lewy bodies

Original Article

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