Acral lentiginous melanoma and mucosal melanoma expressed less programmed-death 1 ligand than cutaneous melanoma: a retrospective study of 73 Japanese melanoma patients.

Acral lentiginous melanoma and mucosal melanoma expressed less programmed-death 1 ligand than cutaneous melanoma: a retrospective study of 73 Japanese melanoma patients.

Publication date: Jun 12, 2019

The treatment of advanced melanoma has been dramatically improved by the introduction of immune checkpoint inhibitors (ICIs). Previous studies indicated that blockading anti-PD-1 antibodies is more effective than anti-CTLA-4 antibodies . However, the response to anti-PD-1 antibodies in cases of acral lentiginous melanoma (ALM) and mucosal melanoma (MCM), the common melanoma types in Asians, is poorer than in cutaneous melanoma (CM), the major type in Caucasians . Since PD-L1 expression is an important biomarker for predicting tumor responses to anti-PD-1 antibodies, we speculated that the low responses to anti-PD-1 antibodies in ALM and MCM may be due to lower PD-L1 expression compared to CM. This article is protected by copyright. All rights reserved.

Nakamura, Y., Ishitsuk, Y., Tanak, R., Okiyama, N., Saito, A., Watanabe, R., and Fujisawa, Y. Acral lentiginous melanoma and mucosal melanoma expressed less programmed-death 1 ligand than cutaneous melanoma: a retrospective study of 73 Japanese melanoma patients. 22942. 2019 J Eur Acad Dermatol Venereol.

Concepts Keywords
Antibodies Retrospective Japanese melanoma
Biomarker Tumor
Caucasians Immune system
CM Medicine
Japanese Organ systems
Ligand Medical specialties
Melanoma Acral lentiginous melanoma
Tumor Checkpoint inhibitor
Immune checkpoint
Mucosal melanoma
Cancer immunotherapy
Antibodies

Semantics

Type Source Name
disease MESH tumor
gene UNIPROT CD274
gene UNIPROT MMUT
gene UNIPROT PIK3CA
gene UNIPROT CTLA4
gene UNIPROT PDCD1
gene UNIPROT RPL17
gene UNIPROT MTUS1
gene UNIPROT MTUS2
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
disease DOID cutaneous melanoma
disease MESH death
disease DOID mucosal melanoma
disease DOID Acral lentiginous melanoma

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *