The Pathogenesis and Clinical Management of Cutaneous Melanoma: An Evidence-Based Review.

The Pathogenesis and Clinical Management of Cutaneous Melanoma: An Evidence-Based Review.

Publication date: Jun 14, 2019

Cutaneous malignant melanoma (CM) is the leading cause of skin cancer-related mortality and accounts for approximately 1,250 deaths in Canada each year. It is also one of few cancers continuing to display rates of increasing incidence throughout the world. The past decade has brought significant growth in our understanding of the pathogenesis and clinical management of CM. This evidence-based review synthesizes that knowledge, beginning with a review of the epidemiology and etiology of the disease followed by a broad review of the roles of diagnostic imaging in its management. Special attention is given to the role of F-fluorodeoxyglucose (F-FDG) positron emission tomography-computed tomography (PET/CT) in supporting assessment at primary presentation of disease, follow-up to surgical and nonsurgical treatment, and for the surveillance of high-risk asymptomatic patients. After a brief review of current treatment options, this article concludes with a demonstration of how and when uncertainty exists at the point of care systematic review processes may be used to resolve clinical questions. Learning Objectives: By the end of this Continuing Medical Education article, participants will be able to 1. Describe the epidemiology and etiology of cutaneous melanoma, 2. Describe broadly the role of diagnostic imaging in the clinical management of cutaneous melanoma, 3. Describe the specific roles and limitations of F-FDG PET/CT in the clinical management of cutaneous melanoma, 4. Describe broadly the best practice in the treatment of cutaneous melanoma, 5. Define the value of systematic review for synthesizing knowledge pertaining to a specific clinical question, and 6. Discuss the utility of F FDG PET/CT in the management of early-stage (AJCC 0-IIc) cutaneous melanoma. This is a CME article and provides the equivalent of 2 hours of continuing education that may be applied to your professional development credit system. A 12-question multiple choice quiz follows this reading. Please note that no formalized credit (Category A) is available from CAMRT.

Burns, D., George, J., Aucoin, D., Bower, J., Burrell, S., Gilbert, R., and Bower, N. The Pathogenesis and Clinical Management of Cutaneous Melanoma: An Evidence-Based Review. 22995. 2019 J Med Imaging Radiat Sci.

Concepts Keywords
AJCC Diagnostic imaging management
Asymptomatic Clinical management
Canada Skin cancer
CM Medicine
Computed Tomography Neuroimaging
Continuing Education Medical physics
Diagnostic Imaging Branches of biology
Epidemiology Medicinal radiochemistry
Etiology Clinical medicine
FDG Melanoma
Fluorodeoxyglucose Nuclear medicine
Incidence Fludeoxyglucose
Malignant Melanoma Positron emission tomography
Melanoma PET-CT
Mortality Medical imaging
Multiple Choice Tomography
Pathogenesis Diagnostic imaging
PET CT
Positron Emission Tomography
Sci
Skin Cancer
Surveillance

Semantics

Type Source Name
pathway BSID Melanoma
disease MESH diagnosis
disease MESH multiple
gene UNIPROT BEST1
disease MESH uncertainty
gene UNIPROT SMUG1
disease MESH growth
gene UNIPROT EHD1
disease MESH cancers
disease DOID skin cancer
disease MESH skin cancer
disease DOID malignant melanoma
disease MESH malignant melanoma
disease DOID Cutaneous Melanoma

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