A Study of Dengue Virus-1 #45AZ5, in Advanced Melanoma

A Study of Dengue Virus-1 #45AZ5, in Advanced Melanoma

Publication date: Jun 18, 2019

Open-label, single-arm multi-center, Phase Ia study to evaluate the safety, optimum dosage, efficacy, survival, Biomarker changes, and immunological responses of DV-1 #45AZ5 in patients with unresectable melanoma who are progressing on standard-of-care therapies. This study will be undertaken in both male and female adult patients with unresectable Stage III and Stage IV melanoma. Patients must have at least one (1) tumor mass available for injection of DV-1 #45AZ5.

Concepts Keywords
AIDS 45AZ5 unresectable melanoma
ANC Tumor
Antagonist G eczema psoriasis
Antibody Atopic dermatitis
Antigen Controlled thyroid disease
Aspirin Tumors
Atopic Dermatitis Squamous carcinoma
Atrial III Stage melanoma
Autoantibodies Eligible CNS metastases
Autoimmune Rheumatoid arthritis
Autoimmune Disease Flavivirus infections
Basal Autoimmune thrombocytopenia
Bilirubin Myocardial infarction
Biomarker Unstable angina
Biopsy Observation tumor
Bone Marrow Systemic lupus
BRAF 45AZ5 Dengue
BRAF Inhibitor Clinical autoimmune disease
Cardiac Arrhythmias Efficacy tumor
Cardiovascular Infection fever
Central Nervous System Design toxicity tumor
Cervix Syndrome
Chemotherapy Metastatic melanoma
Computerized Tomography Contraception
Congestive Heart Failure Angioplasty
Contraception Immunosuppressive therapy
Cooperative Group Vaccinations
Coronary Angioplasty Investigational therapy
Creatinine Chemotherapy
Dengue Fever Radiotherapy
Dengue Virus Medicine
Dermatological Clinical medicine
Dimension Health
Eczema Antineoplastic drugs
ELISA Cancer treatments
Encephalitis Bristol-Myers Squibb
Endocrinopathy Immune system
Erythematous Breakthrough therapy
Fever Ipilimumab
Flavivirus Melanoma
HCV Checkpoint inhibitor
Hepatic Magnetic Resonance Imaging
Hepatitis Tomography
HIV Chemotherapy
Immune System Ultrasound
Immunodeficiency Transplantation
Immunosuppressive MRI
Immunosuppressive Therapy
Infection
Informed Consent
Inhibitor
Ipilimumab
Keratosis
Lactating
Lupus
Lymphocyte
Magnetic Resonance Imaging
Malignancy
Melanoma
Metastases
Metastasis
Microliter
MRI
Multiple Sclerosis
Mutation
Myocardial Infarction
Nile
NSAIDs
Oncology
Organ
Oxaloacetate
Platelet
Prednisone
Pregnancy Test
Psoriasis
Radiotherapy
Renal
Rheumatoid Arthritis
Serologic
Serology
Serotype
SGOT
SGPT
Splenectomy
Squamous Carcinoma
Steroid
Subcutaneous
Syndrome
Systemic Infection
Targeted Therapy
Tetravalent
Thrombocytopenia
Thyroid Disease
Toxicity
Transaminase
Tumor
Ulcers
Ultrasound
Unstable Angina
Urine
Vaccine
Ventricular
Virus
WBC
West Nile Virus
White
Yellow Fever

Semantics

Type Source Name
disease MESH Dengue
disease MESH Melanoma
disease DOID Melanoma
pathway BSID Melanoma
gene UNIPROT AKR1A1
gene UNIPROT ARMC9
disease MESH multi
disease MESH tumor
gene UNIPROT FBN1
disease DOID Cancer
disease MESH Death
gene UNIPROT RPL17
gene UNIPROT PDCD1
gene UNIPROT CD274
gene UNIPROT CTLA4
gene UNIPROT BRAF
disease MESH renal
drug DRUGBANK Creatinine
gene UNIPROT WASHC1
disease MESH metastases
gene UNIPROT CYREN
disease MESH St. Louis Encephalitis
disease DOID St. Louis Encephalitis
disease MESH Yellow Fever
disease DOID Yellow Fever
disease DOID lupus
disease MESH rheumatoid arthritis
disease DOID rheumatoid arthritis
pathway BSID Rheumatoid arthritis
disease MESH multiple sclerosis
disease DOID multiple sclerosis
disease MESH autoimmune thrombocytopenia
disease MESH thyroid disease
disease MESH autoimmune disease
disease DOID autoimmune disease
disease MESH infection
pathway BSID Immune System
disease MESH acquired immuno-deficiency syndrome
disease DOID AIDS
disease MESH hepatitis
disease DOID hepatitis
drug DRUGBANK Prednisone
disease MESH eczema
disease DOID eczema
disease MESH psoriasis
disease DOID psoriasis
disease MESH ulcers
disease MESH atopic dermatitis
disease DOID atopic dermatitis
disease MESH Keratosis Follicularis
disease DOID Keratosis Follicularis
disease MESH cardiovascular disease
disease MESH congestive heart failure
disease DOID congestive heart failure
disease MESH myocardial infarction
disease DOID myocardial infarction
gene UNIPROT EHD1
disease MESH unstable angina
disease DOID unstable angina
disease MESH cardiac arrhythmias
drug DRUGBANK Ipilimumab
drug DRUGBANK Nivolumab
drug DRUGBANK Pembrolizumab
disease MESH flavivirus infections
drug DRUGBANK Acetylsalicylic acid
gene UNIPROT NR4A2
gene UNIPROT ALG3

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