A Trial of BI 765063 Monotherapy and in Combination With BI 754091 in Patients With Advanced Solid Tumours

A Trial of BI 765063 Monotherapy and in Combination With BI 754091 in Patients With Advanced Solid Tumours

Publication date: Jun 18, 2019

This trial will be a two steps Phase I clinical study in patients with advanced solid tumors with an escalating phase (Step 1) followed by an expansion phase (Step 2) of BI 765063, a monoclonal antibody (mAb) antagonist to signal regulatory protein alpha (SIRPα) receptor, a myeloid checkpoint inhibitor administered as single agent, and in combination with BI 754091, a mAb antagonist to PD-1 receptor, a lymphocyte T checkpoint inhibitor.

Concepts Keywords
Adverse Event Hypertension
Alanine Transaminase Tumor
Alcohol Brain metastases
Allele NSCLC
Alleles Hypothyroidism
Alopecia Related metabolic disorders
ALT Archival tumor
ANC Tumour
Antagonist Severe conduction disorders
Anticoagulation Active invasive cancers
Antiviral Significant ventricular arrhythmia
Aspartate Transaminase Ventricular fibrillation
AST Angina
Asthma Hepatitis
Atopy Basal carcinoma
Atrial Persistent ventricular tachycardia
Autoimmune Syndrome
Autoimmune Disease Significant chronic liver
Basal Alcohol drug abuse
Bilirubin Radiation therapy
Biopsies Contraception
Biopsy Blood transfusion
Blood Investigational therapy
Blood Transfusion Chemotherapy
Bone Fracture Surgery
Brain Imaging Immunotherapy
Breastfeeding Anticancer therapies
Cap Medicine
Carcinoma Clinical medicine
Cardiac Dysrhythmia Health
Central Nervous System RTT
Cervix Cancer treatments
Chemotherapy Radiation therapy
Cirrhosis Chemotherapy
CKD Breast cancer
Clinical Examination Estrogen
Condoms Melanoma
Congestive Heart Failure Sorafenib
Contraception Alpha
Contraceptives Radiation
Cooperative Group Immunotherapeutics
Coronary Artery Antibodies
Corticosteroids Chemotherapy
Creatinine MRI
Creatinine Clearance
Cytologically
Diabetes
Diabetes Mellitus
Diaphragm
DNA
Drug Abuse
ECG
Estrogen
Failure Rate
Fibrosis
Formula
Gastric Cancer
HbsAg
HBV
HCV
Hemoglobin
Heparin
Hepatitis
Heterozygous
Histologically
HIV
Homozygous
Hormonal Contraception
Hormone
Hypercalcemia
Hypertension
Hypothyroidism
Immunosuppressive
Immunosuppressive Drugs
Immunosuppressive Medication
Immunotherapy
Infection
Informed Consent
Infusion
INR
Insulin
Intrauterine Device
IUD
Lesion
Liver
Lung
Lymphocyte
Malignancies
Melanoma
Menses
Metabolic Disorders
Metastases
Metastasis
Metastatic
Monoclonal Antibodies
Monoclonal Antibody
MRI
Myeloid
Myocardial Infarction
NCI
OSE
Ovarian Cancer
Ovulation
Palliative Care
Pancreatic Cancer
Platelet Count
Pneumonitis
Polymorphism
Postmenopausal
Prednisolone
Pregnancy Test
Primary Tumor
Progestogen
Protocol
QTc Interval
Radiation
Radiation Therapy
Receptor
Serum
Sexual Abstinence
SIADH
Social Security
Sorafenib
Spermicide
Sponge
Steroids
Sunitinib
Syndrome
Systemic Therapy
Targeted Therapy
Thyroid
TNBC
Topical
Transdermal
Tumor
Tumour
Tyrosine Kinase Inhibitor
Unstable Angina
Ventricular
Ventricular Arrhythmia
Ventricular Fibrillation
Ventricular Tachycardia
Vitamin
Vitamin K
Vitiligo

Semantics

Type Source Name
gene UNIPROT KRT7
gene UNIPROT XRCC1
disease DOID RCC
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
pathway BSID Pancreatic cancer
disease DOID pancreatic cancer
disease MESH pancreatic cancer
disease DOID NSCLC
gene UNIPROT DNMT3B
gene UNIPROT PDCD1
gene UNIPROT RPL17
gene UNIPROT SIRPA
gene UNIPROT PTPN5
disease MESH tumors
gene UNIPROT SCLY
gene UNIPROT TAL1
disease MESH gastric cancer
disease DOID gastric cancer
disease MESH ovarian cancer
disease DOID ovarian cancer
disease MESH metastasis
gene UNIPROT IK
gene UNIPROT DYRK3
gene UNIPROT SLC17A5
drug DRUGBANK L-Alanine
drug DRUGBANK Creatinine
disease MESH Chronic Kidney Disease
disease DOID Chronic Kidney Disease
gene UNIPROT TFPI
drug DRUGBANK Phylloquinone
drug DRUGBANK Heparin
drug DRUGBANK Sunitinib
drug DRUGBANK Sorafenib
disease MESH alopecia
disease DOID alopecia
disease MESH estrogen
gene UNIPROT CAP1
gene UNIPROT LNPEP
gene UNIPROT HACD1
gene UNIPROT BRD4
gene UNIPROT SORBS1
gene UNIPROT SERPINB6
gene UNIPROT CYREN
disease MESH spinal cord compression
gene UNIPROT FBN1
disease MESH basal cell carcinoma
disease DOID basal cell carcinoma
pathway BSID Basal cell carcinoma
disease DOID in situ carcinoma
disease MESH autoimmune disease
disease DOID autoimmune disease
disease MESH vitiligo
disease DOID vitiligo
disease MESH asthma
disease DOID asthma
pathway BSID Asthma
gene UNIPROT MS4A2
disease MESH hypothyroidism
disease DOID hypothyroidism
disease MESH Type 1 diabetes mellitus
disease DOID Type 1 diabetes mellitus
gene UNIPROT CD274
gene UNIPROT MAX
drug DRUGBANK Prednisolone
disease MESH interstitial lung disease
disease DOID interstitial lung disease
disease MESH pneumonitis
disease MESH hypercalcemia
disease DOID hypercalcemia
disease MESH SIADH
disease MESH congestive heart failure
disease DOID congestive heart failure
disease MESH hypertension
disease DOID hypertension
disease MESH heart disease
disease DOID heart disease
disease MESH coronary artery disease
disease DOID coronary artery disease
disease MESH unstable angina
disease DOID unstable angina
disease MESH myocardial infarction
disease DOID myocardial infarction
disease MESH ECG
disease MESH abnormalities
disease MESH cardiac dysrhythmia
disease MESH ventricular tachycardia
disease MESH ventricular fibrillation
gene UNIPROT KIDINS220
disease MESH liver disease
disease DOID liver disease
disease MESH fibrosis
disease DOID cirrhosis
disease MESH infection
drug DRUGBANK Hepatitis B Vaccine (Recombinant)
disease MESH hepatitis B
disease DOID hepatitis B
pathway BSID Hepatitis B
drug DRUGBANK Ethanol
disease MESH drug abuse

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