A Study of Infusion of Autologous Melanoma Lysate Pulsed Dendritic Cells With Dengue Virus-1 #45AZ5 in Advanced Melanoma

A Study of Infusion of Autologous Melanoma Lysate Pulsed Dendritic Cells With Dengue Virus-1 #45AZ5 in Advanced Melanoma

Publication date: Jun 19, 2019

Open-label, single-arm multi-center, Phase Ia study to evaluate the safety, optimum dosage, efficacy, Biomarker changes, and immunological responses of Dengue Virus (DV)-1 #45AZ5 and autologous tumor lysate pulsed Dendritic Cells (DC) in patients with unresectable melanoma who are progressing on standard-of-care therapies. This study will be undertaken in both male and female adult patients with unresectable Stage III and Stage IV melanoma. Patients must have at least one (1) tumor mass available for injection of DV-1 #45AZ5 and sufficient tumor available for

Concepts Keywords
AIDS Tumor
AJCC G eczema psoriasis
ANC AZ5 autologous tumor
Antagonist Atopic dermatitis
Antibody G observation tumor
Antigen Controlled thyroid disease
Aspirin Tumors
Assay Squamous carcinoma
Atopic Dermatitis III Stage melanoma
Atrial Syndrome autoimmune thrombocytopenia
Autoantibodies Rheumatoid arthritis
Autoimmune 45AZ5 autologous tumor
Autoimmune Disease Myocardial infarction
Autologous Unstable angina
Basal Systemic lupus
Bilirubin Clinical autoimmune disease
Biomarker Efficacy tumor
Biopsy Infection fever
Bone Marrow Design toxicity tumor
BRAF Contraception
BRAF Inhibitor Angioplasty
Cardiac Arrhythmias Immunosuppressive therapy
Cardiovascular Vaccinations
Central Nervous System Investigational therapy
Cervix Chemotherapy
Chemotherapy Radiotherapy
Computerized Tomography Medicine
Congestive Heart Failure Clinical medicine
Contraception Cancer treatments
Cooperative Group Antineoplastic drugs
Coronary Angioplasty Bristol-Myers Squibb
Creatinine Breakthrough therapy
CTLA4 Oncology
Dendritic Cells Melanoma
Dengue Fever Ipilimumab
Dengue Virus Nivolumab
Dermatological Radiation therapy
Dimension Magnetic Resonance Imaging
Eczema Tomography
ELISA Chemotherapy
Encephalitis Ultrasound
Endocrinopathy Transplantation
Erythematous MRI
Fever
Flavivirus
HCV
Hepatic
Hepatitis
HIV
Immune System
Immunodeficiency
Immunosuppressive
Immunosuppressive Therapy
Infection
Informed Consent
Infusion
Inhibitor
Ipilimumab
Keratosis
Lactating
Lupus
Lymphocyte
Lysate
Magnetic Resonance Imaging
Melanoma
Metastases
Metastasis
Microliter
Monocytes
MRI
Multiple Sclerosis
Mutation
Myocardial Infarction
Nile
NSAID
Oncology
Organ
Oxaloacetic Acid
PDL
Platelet
Prednisone
Pregnancy Test
Psoriasis
Radiotherapy
Renal
Rheumatoid Arthritis
Serologic
Serology
Serotype
SGOT
SGPT
Splenectomy
Squamous Carcinoma
Steroid
Subcutaneous
Syndrome
Systemic Infection
Targeted Therapy
Tetravalent
Thrombocytopenia
Thyroid Disease
Toxicity
Transaminase
Tumor
Ulcers
Ultrasound
Unstable Angina
Urine
Vaccine
Ventricular
Virus
WBC
West Nile Virus
White
Yellow Fever

Semantics

Type Source Name
gene UNIPROT CYREN
disease MESH metastases
gene UNIPROT WASHC1
drug DRUGBANK Creatinine
disease MESH renal
gene UNIPROT CD274
gene UNIPROT PDCD1
gene UNIPROT RPL17
gene UNIPROT BRAF
gene UNIPROT CTLA4
disease MESH Death
disease DOID Cancer
gene UNIPROT FBN1
disease MESH Melanoma
disease DOID Melanoma
pathway BSID Melanoma
disease MESH Dengue
gene UNIPROT AKR1A1
gene UNIPROT ARMC9
disease MESH multi
disease MESH tumor
disease MESH autoimmune disease
disease MESH thyroid disease
disease MESH autoimmune thrombocytopenia
disease DOID multiple sclerosis
disease MESH multiple sclerosis
pathway BSID Rheumatoid arthritis
disease DOID rheumatoid arthritis
disease MESH rheumatoid arthritis
disease DOID lupus
disease DOID Yellow Fever
disease MESH Yellow Fever
disease DOID St. Louis Encephalitis
disease MESH St. Louis Encephalitis
disease DOID autoimmune disease
disease MESH infection
pathway BSID Immune System
disease MESH acquired immuno-deficiency syndrome
disease DOID AIDS
disease MESH hepatitis B
disease DOID hepatitis B
pathway BSID Hepatitis B
drug DRUGBANK Prednisone
disease MESH eczema
disease DOID eczema
disease MESH psoriasis
disease DOID psoriasis
disease MESH ulcers
disease MESH atopic dermatitis
disease DOID atopic dermatitis
disease MESH Keratosis Follicularis
disease DOID Keratosis Follicularis
disease MESH cardiovascular disease
disease MESH congestive heart failure
disease DOID congestive heart failure
disease MESH myocardial infarction
disease DOID myocardial infarction
gene UNIPROT EHD1
disease MESH unstable angina
disease DOID unstable angina
disease MESH cardiac arrhythmias
drug DRUGBANK Ipilimumab
drug DRUGBANK Nivolumab
drug DRUGBANK Pembrolizumab
disease MESH flavivirus infections
drug DRUGBANK Acetylsalicylic acid
gene UNIPROT NR4A2
gene UNIPROT ALG3

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