Dr. Hussein Tawbi on Efficacy and Safety Results From the CheckMate 204 Melanoma Trial

Dr. Hussein Tawbi on Efficacy and Safety Results From the CheckMate 204 Melanoma Trial

Publication date: Jun 18, 2019

Dr. Hussein Tawbi on Efficacy and Safety Results From the CheckMate 204 Melanoma Trial Cancer Network spoke with Hussein Tawbi, MD, PhD, of MD Anderson Cancer Center, about the efficacy and safety of the combination of nivolumab plus ipilimumab in patients with symptomatic melanoma brain metastases. Patients with bilateral uveal melanoma, especially when coincident with remote systemic cancers or a family history of cancer, should be evaluated for germlineBAP1 mutation. Lifelong monitoring for related systemic malignancies is advised. Ocul Oncol Pathol Brain metastases are the most common intracranial tumours and occur in 20-40% of all cancer patients. Lung cancer, breast cancer, and melanoma are the most frequent primary cancer to develop brain metastases. Anatomical magnetic resonance imaging (MRI) of the tumour (in particular post-Gadolinium T1-weighted and T2-weighted FLAIR) provide information about lesion morphology and structure, and are routinely used in clinical practice for both detection and treatment resp. .. Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review Recently, two phase II trials showed intracranial activity of the immune checkpoint inhibitors nivolumab and ipilimumab in patients with melanoma brain metastases. The structure of the lead compound and the regions for SAR Conclusions: FBY BNCT provides excellent control over the growth of B16F10 melanoma cancer. Moreover, FBY holds great potential for being an efficient theranostic agent for imaging guided BNCT for the brain tumor, the lung and the liver metastases by offering a possible solution of measuring local boron concentration via PET imaging.

Concepts Keywords
Assay Bristol-Myers Squibb
Bax RTT
Biphenyl Antineoplastic drugs
Boron Melanoma
BRAF Clinical medicine
Brain Organ systems
Brain Tumor Medicine
Brain Tumors Immunotherapy
Breast Cancer Brain radiotherapy
Cancer Stereotactic radiosurgery
Central Nervous System Metastatic melanoma
CpG MRI
CTLA4 Pharmacokinetics
Epigenetic Magnetic resonance imaging
Essential Oil Checkpoint inhibitor
FEO Nivolumab
Frankincense Ipilimumab
Gadolinium Uveal melanoma
Genome Immune system
Homolog Growth tumor
Immunotherapy PatholBrain metastases
Indicative Common intracranial tumours
Insurance Sarcoma
Ipilimumab Cancers
Lead Compound Uveal melanoma
Lesion Magnetic resonance imaging
Ligands
Liver
Logistic Regression
Lung
Lung Cancer
Magnetic Resonance Imaging
Malignancies
Malignant Melanoma
Melanoma
Metabolizing Enzymes
Metastases
Metastasized
Methylation
Molar
Morphology
MRI
Multivariate
Murine
Mutation
Oncogene
PET
PET Imaging
Pharmacodynamic
Pharmacokinetic
Pharmacokinetics
Pharmacology
Pharmacophore
PhD
PRF1
Radiolabeling
Radiotherapy
Raf
Receptor
Sarcoma
Small Molecule
Stereotactic Radiosurgery
Surgical Resection
T2 Weighted
Targeted Therapies
Theranostic
Tumor
Tumour
Uveal Melanoma
Viral
Vivo

Semantics

Type Source Name
drug DRUGBANK Boron
gene UNIPROT RXFP2
disease MESH growth
gene UNIPROT SARDH
gene UNIPROT NR1I2
gene UNIPROT SRL
gene UNIPROT PRF1
gene UNIPROT ZNF395
gene UNIPROT GZMA
pathway BSID Methylation
disease MESH metastases
drug DRUGBANK Ipilimumab
drug DRUGBANK Nivolumab
gene UNIPROT PDC
disease DOID Cancer
disease MESH Cancer
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma
gene UNIPROT CD274
gene UNIPROT LARGE1
drug DRUGBANK Gadolinium
gene UNIPROT SLC35G1
gene UNIPROT CYREN
disease DOID uveal melanoma
disease MESH uveal melanoma
disease DOID central nervous system tumors
disease MESH central nervous system tumors
gene UNIPROT IMPACT
gene UNIPROT KIAA1549
disease DOID sarcoma
disease MESH sarcoma
gene UNIPROT ZHX2
disease MESH Brain Tumors
gene UNIPROT BRAF
gene UNIPROT COX5A
gene UNIPROT COX8A
gene UNIPROT CPOX
gene UNIPROT AMACR
gene UNIPROT TNFRSF11A
gene UNIPROT BAX
gene UNIPROT BCL2
gene UNIPROT CTLA4
gene UNIPROT PDCD1

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