Study of TQB2450 Combined With Anlotinib in Subjects With Advanced Acral Malignant Melanoma

Study of TQB2450 Combined With Anlotinib in Subjects With Advanced Acral Malignant Melanoma

Publication date: Jun 19, 2019

TQB2450 is a humanized monoclonal antibody targeting programmed death ligand-1 (PD-L1), which prevents PD-L1 from binding to PD-1 and B7.1 receptors on T cell surface, restores T cell activity, thus enhancing immune response and has potential to treat various types of tumors.

Concepts Keywords
Alanine Transaminase Immune system
Alopecia Hepatitis
ALT Healthcare-associated infections
Antibody RTT
Antigen Clinical medicine
Antiviral Medical specialties
APTT Medicine
Arrhythmias Drainage
Ascites Immunosuppression
AST Contraception
Asthma Radiotherapy
Autoimmune Chemotherapy surgery
Autoimmune Disease Hormone replacement
Autoimmune Hepatitis Immunosuppressive therapy
Basal Diabetes mellitus hypothyroidism
Bilirubin Mental disorders
Biopsy Hepatitis chronic hepatitis
Bleeding History liver diseases
Blood Pressure Active HBV infection
Breastfeeding HBV
Bronchiectasis Uncontrollable pleural effusion
Carcinoma HIV
Cervix Cancerous meningitis
Chemotherapy Congestive heart failure
Clinical History Uncontrollable disease
Colony Tumor
Colony Stimulating Factor Malignant melanoma
Condoms Intestinal obstruction
Congestive Heart Failure Autoimmune hepatitis
Contraception Viral hepatitis
Contraceptives Chemotherapy
Cooperative Group Chemotherapy
Creatinine
Cytologically
Cytotoxic T Lymphocyte
Diabetes Mellitus
Diarrhea
Diastolic Blood Pressure
Ejection Fraction
Enteritis
Fluorouracil
Gastrointestinal
Glucose
Granulocyte
HBV
HCV
Hemoglobin
Hepatitis
Histologically
HIV Positive
Hormone
Hormones
Humanized Monoclonal Antibody
Hypersensitivity
Hypothyroidism
Immunosuppression
Immunosuppressive Agents
Immunosuppressive Therapy
Infection
Informed Consent
INR
Intestinal Obstruction
Intrauterine Devices
Ischemic
IU
Lesion
Ligand
Liver
Local Hormones
LVEF
Lymphocyte
Macrophage
Malignancy
Malignant
Malignant Melanoma
Melanoma
Meningitis
Mental Disorders
Mitomycin
MmHg
Monoclonal
Myocardial Infarction
Nephritis
Neutrophils
Pericardial Effusion
Platelets
Pleural Effusion
Pneumonia
Prednisone
Pregnancy Test
Psoriasis
Pyridine
Radiotherapy
Randomization
Receptors
Recombinant
Resection
Swallow
Systolic Blood Pressure
T Cell
Transaminase
Tumor
Tumor Necrosis Factor
Vasculitis
VEGFR
Virus
Vitiligo

Semantics

Type Source Name
drug DRUGBANK Anlotinib
disease MESH Malignant Melanoma
disease DOID Malignant Melanoma
disease MESH death
gene UNIPROT CD274
gene UNIPROT RPL17
gene UNIPROT PDCD1
gene UNIPROT CD80
disease MESH tumors
disease MESH disease progression
drug DRUGBANK Methionine
gene UNIPROT SLTM
gene UNIPROT MET
gene UNIPROT RNMT
gene UNIPROT SLC17A5
drug DRUGBANK L-Alanine
drug DRUGBANK Creatinine
gene UNIPROT ZNF77
disease MESH ventricular ejection fraction
gene UNIPROT KDR
pathway BSID Programmed Cell Death
gene UNIPROT PDCD1LG2
gene UNIPROT TNFRSF9
gene UNIPROT CTLA4
disease MESH Hypersensitivity
disease DOID Hypersensitivity
disease DOID basal cell carcinoma of skin
disease DOID carcinoma in situ of cervix
disease MESH autoimmune disease
disease DOID autoimmune disease
disease MESH autoimmune hepatitis
disease DOID autoimmune hepatitis
disease MESH interstitial pneumonia
disease MESH enteritis
disease MESH vasculitis
disease MESH vasculitis
disease DOID vasculitis
disease MESH nephritis
disease DOID nephritis
disease MESH asthma
disease DOID asthma
pathway BSID Asthma
disease MESH bronchiectasis
disease DOID bronchiectasis
disease MESH vitiligo
disease DOID vitiligo
disease MESH psoriasis
disease DOID psoriasis
disease MESH alopecia
disease DOID alopecia
disease DOID type I diabetes mellitus
pathway BSID Type I diabetes mellitus
disease MESH hypothyroidism
disease DOID hypothyroidism
drug DRUGBANK Prednisone
disease MESH multiple
gene UNIPROT SLC35G1
disease MESH intestinal obstruction
disease DOID intestinal obstruction
disease MESH ascites
disease MESH bleeding
disease MESH metastasis
disease MESH spinal cord compression
disease MESH meningitis
disease DOID meningitis
drug DRUGBANK Fluorouracil
drug DRUGBANK Mitomycin
disease MESH myocardial infarction
disease DOID myocardial infarction
disease MESH congestive heart failure
disease DOID congestive heart failure
disease MESH infections
disease MESH liver diseases
disease DOID viral hepatitis
disease MESH hepatitis B
disease DOID hepatitis B
pathway BSID Hepatitis B
disease MESH hepatitis C
disease DOID hepatitis C
pathway BSID Hepatitis C
disease MESH virus infection
disease DOID virus infection
disease MESH hepatitis
disease DOID hepatitis
disease MESH chronic hepatitis
disease MESH diabetes mellitus
disease DOID diabetes mellitus
disease MESH fasting
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK D-glucose
drug DRUGBANK Filgrastim
gene UNIPROT CSF2
gene UNIPROT LAMC2
drug DRUGBANK Sargramostim
disease MESH mental disorders
disease MESH abnormalities
gene UNIPROT NR4A2
gene UNIPROT ALG3
pathway BSID Melanoma
gene UNIPROT CHIA

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