Publication date: Jun 24, 2019
Inhibiting the function of a protein called sortilin – an important regulator of nerve damage-induced pain in mice – may represent a potentially effective strategy for treating chronic pain in humans, including those with multiple sclerosis, a study in mice suggests. -Once nerve damage has occurred, and the nerve cells go into overdrive, molecules are released which start a domino effect that ultimately triggers pain,” Mette Richner, PhD, professor at Aarhus University and lead author of the study, said in a press release. In other words, neurotensin acts as a -brake” for the pain signals, and sortilin drives these pain signals by inhibiting neurotensin – essentially acting as a -brake for the brake,” the researchers said. -The [pain signals’] domino effect can be inhibited by a particular molecule in the spinal cord called neurotensin, and our studies show that the neurotensin is ‘captured’ by sortilin,” Richner said. -Our research is carried out on mice, but as some of the fundamental mechanisms are quite similar in humans and mice, it still gives an indication of what is happening in people suffering from chronic pain,” said Christian Vaegter, PhD, researcher at Aarhus University and co-senior author of the study.
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