Publication date: Jun 25, 2019
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune demyelinating disease. Its pathogenesis involves humoral and cellular immunity, with production of pro- and anti-inflammatory cytokines by T cells.
To analyze the cytokine profile of cerebrospinal fluid (CSF) T cells in patients with relapsing-remitting MS (RRMS) and non-inflammatory controls.
T cell cytokine production was analyzed by flow cytometry in CSF samples collected from 34 untreated RRMS patients and 20 age-matched controls. Immunofluorescence studies were performed in spinal cord MS active lesions.
Percentages of CSF-derived IL-17A, IL-17A/IL-22, and IL-17A/GM-CSF producing T cells were significantly higher in RRMS patients compared to controls. Percentages of T cells producing IFN-γ were lower in RRMS patients compared to controls. Patients in relapse showed higher percentages of CD4 T cells producing IL-13 and GM-CSF compared to patients in remission. We found a positive correlation between percentages of IL-13 T cells and the Expanded Disability Status Scale (EDSS; ρ = 0.5; p
Ghezzi, L., Cantoni, C., Cignarella, F., Bollman, B., Cross, A.H., Salter, A., Galimberti, D., Cella, M., and Piccio, L. T cells producing GM-CSF and IL-13 are enriched in the cerebrospinal fluid of relapsing MS patients. 18416. 2019 Mult Scler.
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