B Cells and Melanoma Pathogenesis.

B Cells and Melanoma Pathogenesis.

Publication date: Jul 01, 2019

Melanoma is one of the deadliest cancers. In this issue, Kobayashi et al. (2019) demonstrate a novel role for tumor-infiltrating innate-like B1a B cells in promoting melanoma growth. IL-10 (B1a) regulatory B cells accumulate selectively in melanomas, and enhance tumor growth through suppression of cytokine production by tumor-infiltrating CD8 T cells and potentially additional IL-10-dependent mechanisms.

Aira, L.E. and Debes, G.F. B Cells and Melanoma Pathogenesis. 23198. 2019 J Invest Dermatol (139):7.

Concepts Keywords
CD8 T cells
Cytokine Tumor
Melanoma Medical specialties
Melanomas Medicine
Tumor Health
RTT
Cancer
Melanomas
Melanoma

Semantics

Type Source Name
drug DRUGBANK Interleukin-10
gene UNIPROT IL10
gene UNIPROT CD8A
disease MESH Melanoma
disease MESH growth
disease MESH cancers
pathway BSID Melanoma
disease DOID Melanoma

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