Publication date: Jul 01, 2019
Melanoma is one of the deadliest cancers. In this issue, Kobayashi et al. (2019) demonstrate a novel role for tumor-infiltrating innate-like B1a B cells in promoting melanoma growth. IL-10 (B1a) regulatory B cells accumulate selectively in melanomas, and enhance tumor growth through suppression of cytokine production by tumor-infiltrating CD8 T cells and potentially additional IL-10-dependent mechanisms.
Aira, L.E. and Debes, G.F. B Cells and Melanoma Pathogenesis. 23198. 2019 J Invest Dermatol (139):7.
- mA mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
- Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell-Mediated Antitumor Immunity.