Influence of social determinants of health and substance use characteristics on persons who use drugs pursuit of care for hepatitis C virus infection.

Influence of social determinants of health and substance use characteristics on persons who use drugs pursuit of care for hepatitis C virus infection.

Publication date: Jul 01, 2019

Social determinants of health (SDOH), i.e., social, behavioral and environmental factors, are increasingly recognized for their important influence on health outcomes. Data are limited on the influence of SDOH, substance use characteristics, and their interactions on pursuit of hepatitis C virus (HCV) care among individuals with opioid use disorder (OUD). Linkage to HCV care remains low in this population despite high HCV prevalence and incidence.

To investigate the influence of SDOH, substance use factors, and their interactions on HCV treatment uptake among OUD patients in a methadone treatment program.

Information on patient demographics, SDOH, substance use characteristics, and co-morbid medical conditions were obtained from the paper and electronic medical records of OUD patients on methadone. We applied multiple correspondence analysis, k-means algorithm, and logistic regression with least absolute shrinkage and selection operator penalty to identify variables and clusters associated with pursuit of HCV care.

Data from 161 patients (57% male, 60% Caucasian, mean age 45 years) were evaluated. Being employed, the absence of support systems, and a history of foster care were the strongest positive predictors of treatment pursuit. The use of crack/cocaine as the initial illicit substance, criminal activity without incarceration, and the absence of a family history of chemical dependency were the strongest negative predictors. We identified clusters among persons with OUD based upon their likelihood to pursue HCV management.

Utilizing data from the medical record, we were able to identify factors positively and negatively associated with linkage-to-care for HCV. We were also able to divide patients into clusters of factors associated with linkage-to-care for HCV. These results could be used to identify individuals with OUD based upon their readiness for HCV care.

Williams, N., Bossert, N., Chen, Y., Jaanim”agi, U., Markatou, M., and Talal, A.H. Influence of social determinants of health and substance use characteristics on persons who use drugs pursuit of care for hepatitis C virus infection. 03695. 2019 J Subst Abuse Treat (102):

Concepts Keywords
Algorithm HCV care
Caucasian HCV treatment
Chemical Dependency HCV
Crack Cocaine Medical specialties
Foster Care Medicine
HCV RTT
Hepatitis Clinical medicine
Incidence Healthcare-associated infections
Infection Viral hepatitis
Logistic Regression HCV
Methadone Methadone
Operator
Opioid
Virus

Semantics

Type Source Name
disease MESH Substance-related disorders
disease DOID Hepatitis
disease MESH Hepatitis
disease MESH Communicable diseases
drug DRUGBANK Cocaine
disease MESH multiple
drug DRUGBANK Methadone
disease DOID virus infection
disease MESH virus infection
pathway BSID Hepatitis C
disease DOID hepatitis C
disease MESH hepatitis C

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