Targeting the tumour microenvironment and T cell metabolism for effective cancer immunotherapy.

Targeting the tumour microenvironment and T cell metabolism for effective cancer immunotherapy.

Publication date: Jul 04, 2019

The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody-mediated blockade of immune checkpoint molecules PD-1 / PD-L1 and CTLA-4 has had a dramatic impact upon the treatment of previously intractable cancers such as malignant melanoma, whilst adoptive cell therapies using chimeric antigen receptor-bearing T cells have proven highly efficacious in B cell leukaemia. Furthermore, significant progress has been made in understanding the mechanisms by which tumours evade or become resistant to these immunotherapies. In this regard, approaches to broaden the applicability and enhance the efficacy of immunotherapies increasingly include modulation of tumuor and immune cell metabolism. In this mini-review we highlight the most recent studies describing novel approaches and targets for the manipulation of the tumour microenvironment and T cell metabolism and describe how these approaches are being combined with current immunotherapies in preclinical studies. This article is protected by copyright. All rights reserved.

Hope, H.C. and Salmond, R.J. Targeting the tumour microenvironment and T cell metabolism for effective cancer immunotherapy. 23274. 2019 Eur J Immunol.

Concepts Keywords
Blockade Mechanisms tumours
Cancer Cancer
Chimeric Antigen Receptor Immunotherapy
Immunotherapies Immunotherapies
Immunotherapy Medicine
Leukaemia Clinical medicine
Malignant Melanoma Immune system
Metabolism Cancer treatments
Modulation Medical specialties
Immunotherapy
Checkpoint inhibitor
Immune checkpoint
Tumor microenvironment

Semantics

Type Source Name
disease DOID malignant melanoma
disease MESH malignant melanoma
gene UNIPROT IMPACT
gene UNIPROT CTLA4
gene UNIPROT CD274
gene UNIPROT PDCD1
gene UNIPROT RPL17
disease DOID cancer
disease MESH cancer
pathway BSID Metabolism

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