Publication date: Apr 18, 2019
Spinal cord demyelination is common in multiple sclerosis (MS) and has been linked to increased disability and progressive clinical course. Spinal cord atrophy shows an especially close relationship to MS-related physical disability, though the relationship between spinal cord lesions/atrophy and health-related quality of life (QOL) has not been explored.
62 patients (53 relapsing MS, 7 secondary progressive, 2 clinically isolated syndrome) from our center underwent 3 T MRI within 30 days of clinical examination and QOL assessment. Upper cervical (C1-C3) spinal cord area (UCCA) was obtained from 3D high-resolution MPRAGE sequences (1 mm isotropic voxels). Cervical spinal cord (C1-C7) lesion count, and cervical and brain T2 hyperintense lesion volumes were calculated. Brain parenchymal fraction (BPF) was obtained from an automated segmentation pipeline. Spearman correlations were assessed between MRI and clinical data. Partial Spearman correlations adjusting for age, disease duration, and BPF assessed the independent association between MRI variables and QOL domains.
UCCA showed an inverse relationship with age (r = -0.330, p = .009), disease duration, (r = -0.444, p
Zurawski, J., Glanz, B.I., Healy, B.C., Tauhid, S., Khalid, F., Chitnis, T., Weiner, H.L., and Bakshi, R. The impact of cervical spinal cord atrophy on quality of life in multiple sclerosis. 18522. 2019 J Neurol Sci (403):