A Phase II Trial of Neoadjuvant Treatment With PD-1 Inhibition (Nivolumab) With or Without IDO Inhibition (BMS-986205) and With or Without CTLA-4 Inhibition (Ipilimumab) in Resectable Stage III or IV Melanoma

A Phase II Trial of Neoadjuvant Treatment With PD-1 Inhibition (Nivolumab) With or Without IDO Inhibition (BMS-986205) and With or Without CTLA-4 Inhibition (Ipilimumab) in Resectable Stage III or IV Melanoma

Publication date: Jul 03, 2019

This research study is studying different immunotherapy regimens as a possible treatment for stage III or IV resectable melanoma.

Concepts Keywords
Adjuvant Ductal carcinoma
Adrenal Insufficiency Psychiatric illness
Allergic Reactions Active infection
Alopecia Melanoma melanoma
Antibody HIV
Antiretroviral Therapy Eligible acral melanoma
Assay Uncontrolled intercurrent illness
Autoimmune History presence hypersensitivity
Azoospermic Natural fight cancer
Bilirubin Treatment disease
Breastfeeding Risk methemoglobinemia
Cancer Antineoplastic drugs
Carcinoma Organ systems
Cardiac Arrhythmia Clinical medicine
Cervix Bristol-Myers Squibb
Clinical Trial Medicine
Clinical Trials Major surgery
Congenital Radiation
Congestive Heart Failure Immunotherapy
Contraception Contraception
Creatinine Antiretroviral therapy
Creatinine Clearance Stereotactic radiosurgery
Cytochrome Hormone replacement
Cytologic Monoclonal antibodies
Dana Farber Ipilimumab
Deficiency Diseases Breakthrough therapy
Diabetes Mellitus Nivolumab
FDA Melanoma
G6PD Targeted therapy
G6PD Deficiency Radiation
General Anesthesia MRI
Hemoglobin
Hemolytic
HIV
HIV Positive
Hormone
Hypersensitivity
Hypothyroidism
Immune System
Immune System Attack
Immunotherapy
Infection
Informed Consent
Inhibitor
Interferon
Investigational Drug
Ipilimumab
IU
Leukocytes
Live Attenuated Vaccines
Malignancy
Melanoma
Metastasis
Methemoglobin
Methemoglobinemia
Methylene Blue
MRI
N1c
Nursing
Organ
Oximetry
PET CT
Physician
Platelets
Pneumonitis
Prednisone
Pregnancy Test
Prostate Cancer
Psoriasis
Psychiatric Illness
Radiation
Randomization
Secondary Treatment
Serotonin Syndrome
Serum
Sperm Donation
Stereotactic Radiosurgery
Steroids
Swallow
T Cell
Targeted Therapy
Tolerability
Toxicity
Traditional Chinese Medicines
Trauma
Unstable Angina
Urine
Uterine Cancer
Venous Blood
Vitiligo
YERVOY

Semantics

Type Source Name
disease DOID Cancer
gene UNIPROT ALG3
gene UNIPROT NR4A2
disease DOID syndrome
disease MESH syndrome
drug DRUGBANK Serotonin
disease MESH adrenal insufficiency
disease DOID uterine cancer
disease MESH uterine cancer
disease DOID ductal carcinoma in situ
pathway BSID Prostate cancer
disease MESH ductal carcinoma in situ
disease MESH prostate cancer
disease DOID prostate cancer
disease DOID skin carcinoma
disease MESH carcinoma in situ
disease MESH death
disease MESH malignancy
gene UNIPROT CYREN
disease MESH G6PD deficiency
gene UNIPROT G6PD
gene UNIPROT UBL4A
drug DRUGBANK Creatinine
gene UNIPROT SLC17A5
gene UNIPROT FH
gene UNIPROT CLEC4D
gene UNIPROT IDO1
gene UNIPROT CTLA4
drug DRUGBANK Ipilimumab
disease MESH Melanoma
disease DOID Melanoma
pathway BSID Melanoma
disease MESH diagnosis
disease DOID cutaneous melanoma
disease MESH congenital
disease DOID methemoglobinemia
disease MESH methemoglobinemia
disease MESH methemoglobin reductase deficiency
disease DOID alopecia
disease MESH alopecia
disease DOID psoriasis
disease MESH psoriasis
disease DOID vitiligo
disease MESH vitiligo
disease DOID hypothyroidism
disease MESH hypothyroidism
disease DOID type I diabetes mellitus
pathway BSID Type I diabetes mellitus
disease DOID Autoimmune disease
disease MESH Autoimmune disease
disease DOID Hepatitis C
pathway BSID Hepatitis C
disease MESH Hepatitis C
disease DOID Hepatitis B
pathway BSID Hepatitis B
disease MESH Hepatitis B
disease MESH cardiac arrhythmia
disease MESH unstable angina pectoris
disease DOID congestive heart failure
disease MESH congestive heart failure
disease MESH infection
disease MESH pneumonitis
disease DOID ILD
drug DRUGBANK Prednisone
drug DRUGBANK Methylene blue
disease DOID hypersensitivity
disease MESH allergic reactions
disease MESH metastases
gene UNIPROT IMPACT
gene UNIPROT SLC35G1
drug DRUGBANK Chorionic Gonadotropin (Human)
gene UNIPROT CGA
disease DOID mucosal melanoma
drug DRUGBANK Nivolumab
gene UNIPROT PDCD1
gene UNIPROT RPL17

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