Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington’s disease.

Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington’s disease.

Publication date: Jul 05, 2019

The volume of the striatal structures has been associated with disease progression in individuals with Huntington’s disease (HD) from North America, Europe, and Australia. However, it is not known whether the gray matter (GM) volume in the striatum is also sensitive in differentiating vulnerability from disease manifestation in HD families from a South-American region known to have high incidence of the disease. In addition, the association of enlarged brain perivascular spaces (PVS) with cognitive, behavioral, and motor symptoms of HD is unknown.

We have analyzed neuroimaging indicators of global atrophy, PVS burden, and GM tissue volume in the basal ganglia and thalami, in relation to behavioral, motor, and cognitive scores, in 15 HD patients with overt disease manifestation and 14 first-degree relatives not genetically tested, which represent a vulnerable group, from the region of Magdalena, Colombia.

Poor fluid intelligence as per the Raven’s Standard Progressive Matrices was associated with global brain atrophy (p = 0.002) and PVS burden (p ≤ 0.02) in HD patients, where the GM volume in all subcortical structures, with the exception of the right globus pallidus, was associated with motor or cognitive scores. Only the GM volume in the right putamen was associated with envy and MOCA scores (p = 0.008 and 0.015 respectively) in first-degree relatives.

Striatal GM volume, global brain atrophy and PVS burden may serve as differential indicators of disease manifestation in HD. The Raven’s Standard Progressive Matrices could be a cognitive test worth to consider in the differentiation of vulnerability versus overt disease in HD.

Del C Vald’es Hern’andez, M., Abu-Hussain, J., Qiu, X., Priller, J., Parra Rodr’iguez, M., Pino, M., B’aez, S., and Ib’a~nez, A. Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington’s disease. 06561. 2019 Brain Behav.

Concepts Keywords
Atrophy Neuroimaging
Australia Striatum
Basal Ganglia Basal ganglia
Brain Perivascular space
Cognitive Gross pathology
Colombia Cerebral atrophy
Differential Branches of biology
Europe Neuroscience
Fluid Intelligence Brain
Global Brain MRI
Globus Pallidus
Gray Matter
Huntington
Incidence
MOCA
Neuroimaging
North America
Putamen
Raven
Striatal
Striatum
Thalami

Semantics

Type Source Name
disease MESH disease progression
gene UNIPROT CYREN
gene UNIPROT DOCK3
disease MESH atrophy
gene UNIPROT PVR

Original Article

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