New PET Scan Radiotracer May Help Identify Early Signs of MS Progression, Study Reports

New PET Scan Radiotracer May Help Identify Early Signs of MS Progression, Study Reports

Publication date: Jul 09, 2019

This post was originally published on this siteA new radiotracer called [F-18]PBR06, used in positron emission tomography (PET) imaging, helps detect changes in the brain’s grey matter that are linked to progressive forms of multiple sclerosis (MS), a study shows. The study, -Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study,” was published in the journal Neurology: Neuroimmunology & Neuroinflammation. However, disability progression in MS is linked with alterations in grey matter, specifically the activation of microglia – the central nervous system’s immune cells – and neuronal loss. In a Phase 1/2 study (NCT02649985), researchers determined whether a new molecule tracer, called [F-18]PBR06, could be used to measure activation of microglia in the grey matter of people with MS using PET. Results showed that, compared with the brains of healthy controls, activation of microglia in grey matter was higher in the MS patients. The post New PET Scan Radiotracer May Help Identify Early Signs of MS Progression, Study Reports appeared first on Multiple Sclerosis News Today.

Concepts Keywords
Amygdala MRI
Ann Romney Tomography
Atrophy White matter
Boston Positron emission tomography
Brain Magnetic resonance imaging
Central Nervous System Translocator protein
Cingulate Gyrus Microglia
Cognition Medicine
Cortical Neuroimaging
Disability Multiple sclerosis
Discrimination Organ systems
Emotion Glial cells
Grey Matter Branches of biology
Hippocampus Disease
Inflammation Multiple sclerosis
KDa MS
Macrophages Evidence inflammation
Magnetic Resonance Imaging Magnetic resonance imaging
Memory
Metabolism
Microglia
Molecule
MRI
Multiple Sclerosis
Myelin
Neurodegeneration
Neurologist
Neurology
Neurons
Organ
Parahippocampus
PET
PET Imaging
PET Scan
Physical Disability
Positron Emission Tomography
Progressive
Protein
Radioactive
Radioisotope
Radiotracer
Thalamus
Tracer
White Matter

Semantics

Type Source Name
disease MESH atrophy
drug DRUGBANK Nonoxynol-9
disease DOID SPMS
disease DOID relapsing-remitting MS
gene UNIPROT TSPO
pathway BSID Metabolism
disease MESH inflammation
gene UNIPROT CYREN
drug DRUGBANK Tropicamide
pathway BSID Release
disease MESH disease progression
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT SLC35G1

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