A novel individualized drug repositioning approach for predicting personalized candidate drugs for type 1 diabetes mellitus.

A novel individualized drug repositioning approach for predicting personalized candidate drugs for type 1 diabetes mellitus.

Publication date: Jul 09, 2019

The existence of high cost-consuming and high rate of drug failures suggests the promotion of drug repositioning in drug discovery. Existing drug repositioning techniques mainly focus on discovering candidate drugs for a kind of disease, and are not suitable for predicting candidate drugs for an individual sample. Type 1 diabetes mellitus (T1DM) is a disorder of glucose homeostasis caused by autoimmune destruction of the pancreatic β-cell. Here, we present a novel single sample drug repositioning approach for predicting personalized candidate drugs for T1DM. Our method is based on the observation of drug-disease associations by measuring the similarities of individualized pathway aberrance induced by disease and various drugs using a Kolmogorov-Smirnov weighted Enrichment Score algorithm. Using this method, we predicted several underlying candidate drugs for T1DM. Some of them have been reported for the treatment of diabetes mellitus, and some with a current indication to treat other diseases might be repurposed to treat T1DM. This study conducts drug discovery via detecting the functional connections among disease and drug action, on a personalized or customized basis. Our framework provides a rational way for systematic personalized drug discovery of complex diseases and contributes to the future application of custom therapeutic decisions.

Zheng, H. A novel individualized drug repositioning approach for predicting personalized candidate drugs for type 1 diabetes mellitus. 04958. 2019 Stat Appl Genet Mol Biol.

Concepts Keywords
Algorithm Drug complex diseases
Autoimmune Observation drug disease
Diabetes Mellitus Disorder
Drug Discovery Drugs kind disease
Glucose Single diabetes
Homeostasis RTT
Kolmogorov Organ systems
Diabetes
Repositioning
Medicine
Health
Diabetes mellitus
Drug repositioning
Drug discovery

Semantics

Type Source Name
disease DOID diabetes mellitus
disease MESH diabetes mellitus
pathway BSID Glucose Homeostasis
disease DOID type 1 diabetes mellitus
disease MESH type 1 diabetes mellitus

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