A Review of Various Antioxidant Compounds and their Potential Utility as Complementary Therapy in Multiple Sclerosis.

A Review of Various Antioxidant Compounds and their Potential Utility as Complementary Therapy in Multiple Sclerosis.

Publication date: Jul 05, 2019

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS). The etiology of this multifactorial disease has not been clearly defined. Conventional medical treatment of MS has progressed, but is still based on symptomatic treatment. One of the key factors in the pathogenesis of MS is oxidative stress, enhancing inflammation and neurodegeneration. In MS, both reactive oxygen and nitrogen species are formed in the CNS mainly by activated macrophages and microglia structures, which can lead to demyelination and axon disruption. The course of MS is associated with the secretion of many inflammatory and oxidative stress mediators, including cytokines (IL-1b, IL-6, IL-17, TNF-α, INF-γ) and chemokines (MIP-1a, MCP-1, IP10). The early stage of MS (RRMS) lasts about 10 years, and is dominated by inflammatory processes, whereas the chronic stage is associated with neurodegenerative axon and neuron loss. Since oxidative damage has been known to be involved in inflammatory and autoimmune-mediated processes, antioxidant therapy could contribute to the reduction or even prevention of the progression of MS. Further research is needed in order to establish new aims for novel treatment and provide possible benefits to MS patients. The present review examines the roles of oxidative stress and non-pharmacological anti-oxidative therapies in MS.

Miller, E.D., Dziedzic, A., Saluk-Bijak, J., and Bijak, M. A Review of Various Antioxidant Compounds and their Potential Utility as Complementary Therapy in Multiple Sclerosis. 18549. 2019 Nutrients (11):7.

Concepts Keywords
Antioxidant Neurology
Autoimmune Senescence
Axon Autoimmune diseases
Central Nervous System Neurological disorders
Chemokines Medical specialties
Conventional Treatment Organ systems
Cytokines Branches of biology
Demyelination Complementary therapy
Etiology MS
IL 17 Inflammation
Inflammation Demyelination
Macrophages Myelin
Microglia Oxidative stress
Multiple Sclerosis Neurodegeneration
Neurodegeneration
Neurodegenerative
Neuron
Nitrogen
Oxidative Damage
Oxidative Stress
Oxygen
Pathogenesis
Pharmacological
Symptomatic Treatment
TNF

Semantics

Type Source Name
pathway BSID Oxidative Damage
disease DOID RRMS
gene UNIPROT CCL2
gene UNIPROT MIP
gene UNIPROT MIPEP
gene UNIPROT TNPO1
gene UNIPROT CBLIF
gene UNIPROT TNF
gene UNIPROT IL17A
gene UNIPROT IL6
disease MESH demyelination
drug DRUGBANK Nitrogen
drug DRUGBANK Oxygen
disease MESH inflammation
pathway BSID Oxidative Stress
disease MESH oxidative stress
disease DOID Multiple Sclerosis
disease MESH Multiple Sclerosis

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