Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab

Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab

Publication date: Jul 10, 2019

Subjects with resectable melanoma will receive neoadjuvant nivolumab followed by surgical resection. Post-operatively, subjects will receive open-label treatment with up to 1 year of adjuvant nivolumab or ipilimumab plus nivolumab as determined by pathologic response at the time of resection.

Concepts Keywords
Adjuvant Consent protocol
Adrenal Treating cancer
ALT Dose
ANC Melanoma
Antibody Ipilimumab
AST Nivolumab
Autoimmune Breakthrough therapy
Bacillus Antineoplastic drugs
Basal Drugs
BCG Bristol-Myers Squibb
Bilirubin Clinical medicine
Blood Major surgery
Breast Carcinoma Cancer therapy
Breastfeeding Contraception
Cancer Surgery
Carcinoma Non infectious pneumonitis
CD4 G breast carcinoma
Cervical Immunosuppressive therapy
Chicken Pox Transfusion blood products
Colony Stimulating Factors Cancer therapy
Contraception Consent protocol
Contraceptive Adrenal pituitary insufficiency
Corticosteroid However intranasal influenza
Corticosteroids HIV
CrCl Seasonal influenza
Creatinine Infectious disease illness
Creatinine Clearance III resectable melanoma
Erythropoietin Unresectable disease
Hemoglobin
Heterosexual
HIV
Immunodeficiency
Immunosuppressive Drugs
Immunosuppressive Therapy
Infection
Infectious Disease
Influenza
Informed Consent
Insulin
Interferon
Intranasal
Investigational Drug
Ipilimumab
IU
Lesion
Live Attenuated Vaccines
Liver
Lung
Malignancy
Measles
Melanoma
Metastases
Mumps
Neoadjuvant
Neuropathy
Organ
Pennsylvania
Pituitary Insufficiency
Platelets
Pneumonitis
Prednisone
Pregnancy Test
Protocol
Rabies
Recombinant
Red Blood Cells
Resection
Rubella
Seasonal Influenza
Serum
SGOT
Squamous Carcinoma
Steroid
Steroids
Substance Abuse
Surgical Oncologist
Surgical Resection
Systemic Therapy
T Cell
T Cell Receptor
Thyroxine
Toxicity
Transfusion
Urine
Vaccine
Varicella Zoster
Viral Load
Virus
Yellow Fever

Semantics

Type Source Name
gene UNIPROT EHD1
disease DOID cervical cancer
disease DOID autoimmune disease
disease MESH autoimmune disease
disease DOID breast carcinoma
disease MESH cervical cancer
disease MESH breast carcinoma
disease MESH carcinoma in situ
pathway BSID Basal cell carcinoma
disease MESH basal cell carcinoma
disease DOID basal cell carcinoma
drug DRUGBANK Prednisone
disease DOID influenza
disease MESH influenza
disease MESH typhoid
disease DOID typhoid
drug DRUGBANK BCG vaccine
disease DOID rabies
disease DOID yellow fever
disease MESH rabies
disease MESH yellow fever
disease MESH zoster
disease DOID varicella
disease MESH varicella
disease DOID rubella
disease MESH rubella
disease DOID mumps
disease MESH mumps
pathway BSID Measles
disease DOID measles
disease MESH measles
drug DRUGBANK Erythropoietin
drug DRUGBANK Sargramostim
drug DRUGBANK Filgrastim
gene UNIPROT DYRK3
gene UNIPROT IK
disease MESH complications
disease DOID neuropathy
gene UNIPROT TLE5
disease DOID cancer
disease MESH cancer
gene UNIPROT IL2
gene UNIPROT TNFRSF9
gene UNIPROT CTLA4
gene UNIPROT CD274
gene UNIPROT PDCD1
gene UNIPROT RPL17
gene UNIPROT ALG3
gene UNIPROT NR4A2
disease MESH metastases
gene UNIPROT SLC17A5
drug DRUGBANK Creatinine
gene UNIPROT RAPGEF5
gene UNIPROT FH
gene UNIPROT CLEC4D
disease DOID mucosal melanoma
disease MESH diagnosis
drug DRUGBANK Ipilimumab
gene UNIPROT SLC35G1
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
drug DRUGBANK Nivolumab
disease MESH pituitary insufficiency
disease DOID pituitary insufficiency
disease MESH interstitial lung disease
disease DOID interstitial lung disease
disease MESH pneumonitis
disease MESH infection
gene UNIPROT CD4
disease MESH viral load
disease DOID Hepatitis B infection
disease MESH Hepatitis C
disease DOID Hepatitis C
pathway BSID Hepatitis C
disease MESH virus infection
disease DOID virus infection
gene UNIPROT BEST1
disease MESH substance abuse
disease DOID substance abuse
disease MESH infectious disease
disease DOID infectious disease
pathway BSID Infectious disease

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