Brain volume dynamics in multiple sclerosis. A case-control study.

Brain volume dynamics in multiple sclerosis. A case-control study.

Publication date: Jul 06, 2019

Objectives: In this study, we aimed to explore the extent and clinical relevance of brain volume dynamics in relapsing remitting multiple sclerosis (RRMS). Methods: Sixty-three patients with RRMS with a disease duration of about 5 years (36 women, mean age 39.9 +/- 9.4 years; mean EDSS1.4 +/- 1.2, mean relapse rate 0.98 +/- 1.17) and 50 healthy control individuals (24 women, mean age 39.1 +/- 10.2 years) were recruited and imaged on a MRI scanner by using post-gadolinium high-resolution3D T1W sequences. Cross-sectional and longitudinal volumetric data were obtained by using SIENA(X) and FIRST software. Results: Patients showed significantly lower subcortical volumes compared to healthy controls. Interestingly, the educational level predicted the rate of right thalamus atrophy. The mean annualized percentage of brain volume change (aPBVC) was -0.92% (+/-1.64%) and was presented in higher rates during the first five years after MS diagnosis. Conclusion: Brain atrophy mainly involved subcortical grey matter structures and was more conspicuous during the first years of MS diagnosis. The buffering role of education in atrophy was also corroborated by this study.

Andravizou, A., Artemiadis, A., Bakirtzis, C., , Siokas, Aloizou, A.M., Peristeri, E., Kapsalaki, E., , Tsimourtou, Hadjigeorgiou, G.M., and Dardiotis, E. Brain volume dynamics in multiple sclerosis. A case-control study. 18547. 2019 Neurol Res.

Concepts Keywords
Atrophy Dynamics multiple sclerosis
Brain MRI Multiple sclerosis
Case Control Study Medical specialties
Gadolinium Cerebral atrophy
Grey Matter Multiple sclerosis
MRI Scanner Medicine
Multiple Sclerosis Clinical medicine
Relapse Multiple sclerosis research
Thalamus MRI


Type Source Name
disease MESH diagnosis
disease MESH atrophy
drug DRUGBANK Gadolinium
disease MESH relapse
disease DOID RRMS
disease MESH relapsing remitting multiple sclerosis
disease DOID multiple sclerosis
disease MESH multiple sclerosis


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