Comparison of Treatment by IM Ketamine to IV Ketamine in Patients With Renal Colic

Comparison of Treatment by IM Ketamine to IV Ketamine in Patients With Renal Colic

Publication date: Jul 10, 2019

Patients who present to the emergency department (ED), with acute pain due to renal colic, are often treated with opioids. Treatment with opioids has many disadvantages – cardio-respiratory depression, nausea, vomiting and long term dependence. For these reasons, there is a constant search for a way to reduce the use of opioids. ketamine has been proven to augmented the analgesic effect of opioids, and thus reduce the use and adverse effects of opioids. Different studies about the use of Ketamine as a sedition agent have shown that Ketamine given IM versus IV has longer duration of effect with less adverse effects. The study we are conducting is designed to test and analyze the safety and efficacy of IV Ketamine with IV Morphine compared to IV Ketamine and morphine with IM placebo in a setting of acute pain due to, or suspected renal colic in the ED. When both ways of administration are given by the protocol as is customary for treatment of pain in the Emergency Medicine department, and will be a prospective, randomized, double blind, controlled study.

Concepts Keywords
Allergies Ways administration protocol
Analgesia Hours chronic analgesia
Analgesic Pain
ASA Vomiting
Blood Pressure Opioid others allergies
Concurrent Drugs
Department Psychoactive drugs
Double Blind Neurochemistry
Heart Rate RTT
Ketamine Euphoriants
MmHg Morphinans
Morphine Opioids
Nausea Ketones
Normal Saline Ketamine
Opioid Morphine
Opioids Pain
Pain Heroin
Physician
Placebo
Protocol
Questionnaire
Respiratory Depression
Sedition
Systolic Blood Pressure
Tel Aviv
Vital Signs
Vomiting

Semantics

Type Source Name
drug DRUGBANK Ketamine
disease MESH Renal
disease MESH Colic
disease MESH emergency
disease MESH respiratory depression
drug DRUGBANK Morphine
drug DRUGBANK Aspartame
drug DRUGBANK Acetylsalicylic acid
gene UNIPROT ARSA
disease DOID analgesia
disease MESH allergies
gene UNIPROT NR4A2
gene UNIPROT ALG3
gene UNIPROT ETV6

Original Article

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