Emerging Novel Pharmacological Non-opioid Therapies in Headache Management: a Comprehensive Review.

Emerging Novel Pharmacological Non-opioid Therapies in Headache Management: a Comprehensive Review.

Publication date: Jul 08, 2019

Chronic headache is a significant worldwide problem despite advances in treatment options. Chronic headaches can have significant a detrimental impact on the activities of daily living.

Patients who do not obtain relief from chronic head and neck pain from conservative treatments are commonly being managed with interventional treatments. These interventional treatment options include botulinum toxin A, injections, local occipital nerve anesthetic and corticosteroid infiltration, occipital nerve subcutaneous stimulation and occipital nerve pulsed radiofrequency (PRF), sphenopalatine ganglion block, and radiofrequency techniques. Recently, evidence has emerged to support non-opioid-based drug and interventional approaches. Overall, more research is necessary to clarify the safety and efficacy of interventional treatments and to better understand the pathogenesis of chronic headache pain.

Kaye, A.D., Motejunas, M.W., Cornett, E.M., Ehrhardt, K.P., Novitch, M.B., Class, J., Siddaiah, H., Hart, B.M., and Urman, R.D. Emerging Novel Pharmacological Non-opioid Therapies in Headache Management: a Comprehensive Review. 03737. 2019 Curr Pain Headache Rep (23):8.

Concepts Keywords
Anesthetic Nociception
Botulinum Toxin Acute pain
Chronic Headache Headaches
Conservative Medicine
Corticosteroid Clinical medicine
Headache Chronic headache
Neck Pain Botulinum toxin
Nerve Occipital neuralgia
Occipital
Opioid
Pain
Pathogenesis
Radiofrequency
Sphenopalatine Ganglion
Subcutaneous

Semantics

Type Source Name
disease DOID analgesia
drug DRUGBANK Tropicamide
gene UNIPROT IMPACT
disease MESH Chronic headache

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