Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics.

Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics.

Publication date: Jul 06, 2019

Melanoma is the leading cause of skin-cancer related deaths in North America. Metastatic melanoma is difficult to treat and chemotherapies have limited success. Furthermore, chemotherapies lead to toxic side effects due to nonselective targeting of normal cells. Curcumin is a natural product of Curcuma longa (turmeric) and has been shown to possess anti-cancer activity. However, due to its poor bioavailability and stability, natural curcumin is not an effective cancer treatment. We tested synthetic analogs of curcumin that are more stable. One of these derivatives, Compound A, has shown significant anti-cancer efficacy in colon, leukemia, and triple-negative inflammatory breast cancer cells. However, the effects of Compound A against melanoma cells have not been studied before. In this study, for the first time, we demonstrated the efficacy of Compound A for the selective induction of apoptosis in melanoma cells and its interaction with tamoxifen, taxol, and cisplatin. We found that Compound A induced apoptosis selectively in human melanoma cells by increasing oxidative stress. The anti-cancer activity of Compound A was enhanced when combined with tamoxifen and the combination treatment did not result in significant toxicity to noncancerous cells. Additionally, Compound A did not interact negatively with the anti-cancer activity of taxol and cisplatin. These results indicate that Compound A could be developed as a selective and effective melanoma treatment either alone or in combination with other non-toxic agents like tamoxifen.

Parashar, K., Sood, S., Mehaidli, A., Curran, C., Vegh, C., Nguyen, C., Pignanelli, C., Wu, J., Liang, G., Wang, Y., and Pandey, S. Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics. 23314. 2019 Molecules (24):13.

Concepts Keywords
Apoptosis Melanoma treatment
Bioavailability Selective effective melanoma
Breast Compound melanoma
Cancer Skin cancer
Chemotherapies Negatively anti cancer
Cisplatin Chemotherapies
Colon Medicine
Curcuma Longa Chemistry
Curcumin Clinical medicine
Interact RTT
Leukemia Chemotherapy
Melanoma Curcumin
Metastatic Melanoma Tamoxifen
Natural Product Melanoma
North America Cancer
Oxidative Stress Paclitaxel
Skin Cancer Cisplatin
Tamoxifen Apoptosis
Taxol Apoptosis
Toxicity
Triple Negative
Turmeric

Semantics

Type Source Name
pathway BSID Oxidative Stress
disease MESH oxidative stress
pathway BSID Apoptosis
drug DRUGBANK Cisplatin
drug DRUGBANK Paclitaxel
drug DRUGBANK Tamoxifen
disease MESH inflammatory breast cancer
disease DOID leukemia
disease MESH leukemia
drug DRUGBANK Spinosad
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma
drug DRUGBANK Curcumin
disease DOID cancer
disease MESH cancer

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *