Genome-wide functional association networks: background, data & state-of-the-art resources.

Genome-wide functional association networks: background, data & state-of-the-art resources.

Publication date: Jul 05, 2019

The vast amount of experimental data from recent advances in the field of high-throughput biology begs for integration into more complex data structures such as genome-wide functional association networks. Such networks have been used for elucidation of the interplay of intra-cellular molecules to make advances ranging from the basic science understanding of evolutionary processes to the more translational field of precision medicine. The allure of the field has resulted in rapid growth of the number of available network resources, each with unique attributes exploitable to answer different biological questions. Unfortunately, the high volume of network resources makes it impossible for the intended user to select an appropriate tool for their particular research question. The aim of this paper is to provide an overview of the underlying data and representative network resources as well as to mention methods of integration, allowing a customized approach to resource selection. Additionally, this report will provide a primer for researchers venturing into the field of network integration.

Open Access PDF

Guala, D., Ogris, C., M”uller, N., and Sonnhammer, E.L.L. Genome-wide functional association networks: background, data & state-of-the-art resources. 04966. 2019 Brief Bioinform.

Concepts Keywords
Genome Genome
Interplay Genetic mapping
Precision Medicine Genomics
Primer Volume network
Throughput Primer venturing network
Venturing Biological databases
Systems biology

Semantics

Type Source Name
gene UNIPROT TRAC
gene UNIPROT NCOR2
drug DRUGBANK Nitroarginine
disease MESH comorbidities
drug DRUGBANK Methylphenidate
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT COL9A2
gene UNIPROT SCN8A
gene UNIPROT INTU
gene UNIPROT SMOC1
disease DOID OAS
gene UNIPROT MAGEE1
gene UNIPROT CBL
drug DRUGBANK Sulodexide
gene UNIPROT TRIM9
gene UNIPROT STAC3
gene UNIPROT RNF2
gene UNIPROT FASTK
drug DRUGBANK Carboxyamidotriazole
gene UNIPROT DGCR2
gene UNIPROT ABCB6
disease DOID cancer
disease MESH cancer
gene UNIPROT PROC
gene UNIPROT FAM168B
pathway BSID Budding
gene UNIPROT CAPG
gene UNIPROT CD46
gene UNIPROT CDCA8
gene UNIPROT EYA1
disease DOID bor
gene UNIPROT TSC1
gene UNIPROT TSC2
gene UNIPROT DUOXA1
gene UNIPROT PDGFB
gene UNIPROT EAF2
gene UNIPROT BCL2L10
gene UNIPROT NBN
gene UNIPROT ELL
gene UNIPROT BRD2
drug DRUGBANK Tropicamide
gene UNIPROT NAGS
gene UNIPROT CPSF4
gene UNIPROT PSMD13
gene UNIPROT RPS11
drug DRUGBANK Caffeine
drug DRUGBANK Theophylline
pathway BSID Metabolism
gene UNIPROT NPL
drug DRUGBANK Nonoxynol-9
gene UNIPROT TNF
disease MESH dif
gene UNIPROT LITAF
gene UNIPROT COPE
gene UNIPROT MTA2
drug DRUGBANK Phenindione
disease DOID PID
gene UNIPROT BRAP
gene UNIPROT IMPA1
disease MESH GUI
gene UNIPROT SET
gene UNIPROT NEUROG1
drug DRUGBANK Gold
gene UNIPROT ATM
drug DRUGBANK Aspartame
gene UNIPROT CCDC88A
gene UNIPROT APEX1
disease DOID APE
gene UNIPROT AP3B1
gene UNIPROT PREP
gene UNIPROT PENK
gene UNIPROT TIMP1
drug DRUGBANK Icosapent
gene UNIPROT SSRP1
gene UNIPROT EHD1
disease MESH multiple
gene UNIPROT FAM107B
gene UNIPROT SGSM3
disease MESH separated
gene UNIPROT FLNB
gene UNIPROT USO1
gene UNIPROT SEC14L2
gene UNIPROT NXF1
disease MESH neighborhood
disease MESH death
drug DRUGBANK Didanosine
gene UNIPROT LARGE1
gene UNIPROT PTPN5
gene UNIPROT HPSE
gene UNIPROT FBN1
gene UNIPROT RAB35
gene UNIPROT SH3YL1
gene UNIPROT SLC35G1
gene UNIPROT MENT
drug DRUGBANK Trestolone
gene UNIPROT STUB1
drug DRUGBANK Silicon dioxide
gene UNIPROT TNFRSF11A
gene UNIPROT NT5E
gene UNIPROT TNFRSF10C
gene UNIPROT FPR1
gene UNIPROT MAPK1IP1L
gene UNIPROT COL17A1
disease MESH multi
gene UNIPROT RXFP2
gene UNIPROT ELK3
gene UNIPROT EPHB1
gene UNIPROT SLC6A2
gene UNIPROT DYRK3
gene UNIPROT IK
gene UNIPROT DUSP4
disease MESH typ
drug DRUGBANK Coenzyme M
gene UNIPROT FURIN
gene UNIPROT NFKBIZ
gene UNIPROT ETV6
pathway BSID Reproduction
gene UNIPROT TNFSF13
gene UNIPROT ANP32B
disease DOID CCM
gene UNIPROT PDC
gene UNIPROT DNMT1
gene UNIPROT CD69
gene UNIPROT CD5L
disease MESH growth
gene UNIPROT ARTN
gene UNIPROT AGRP

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *