IsomiRs and tRNA-derived Fragments are Associated with Metastasis and Patient Survival in Uveal Melanoma.

IsomiRs and tRNA-derived Fragments are Associated with Metastasis and Patient Survival in Uveal Melanoma.

Publication date: Jul 08, 2019

Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults. With over 50% of patients developing metastatic disease, there is an unmet need for improved diagnostic and therapeutic options. Efforts to understand the molecular biology of the disease have revealed several markers that correlate with patient prognosis, including the copy number of chromosome 3, genetic alterations in BAP1, EIF1AX and SF3B1 genes, and other transcriptional features. Here, we expand upon previous reports by comprehensively characterizing the short RNA-ome in 80 primary UVM tumor samples. In particular, we describe a previously-unseen complex network involving numerous regulatory molecules that comprise microRNA (miRNAs), novel UVM specific miRNA loci, miRNA isoforms (isomiRs), and tRNA-derived fragments (tRFs). Importantly, we show that the abundance profiles of isomiRs and tRFs associate with various molecular phenotypes, metastatic disease, and patient survival. Our findings suggest deep involvement of isomiRs and tRFs in the disease etiology of UVM. We posit that further study and characterization of these novel molecules will improve understanding of the mechanisms underlying UVM, and lead to the development of new diagnostic and therapeutic approaches. This article is protected by copyright. All rights reserved.

Londin, E., Magee, R., Shields, C.L., Lally, S.E., Sato, T., and , Rigoutsos. IsomiRs and tRNA-derived Fragments are Associated with Metastasis and Patient Survival in Uveal Melanoma. 23322. 2019 Pigment Cell Melanoma Res.

Concepts Keywords
Chromosome MicroRNA
Complex Network BAP1
Etiology Gene expression
Genetic Transfer RNA
Isoforms Proteins
Loci Uveal melanoma
Malignancy Medicine
Melanoma RNA
Metastasis Melanoma
Metastatic Branches of biology
MicroRNA Metastatic disease
MiRNA Unseen complex network
Phenotypes EIF1AX
Pigment
Prognosis
RNA
TRNA
Tumor
Uveal Melanoma

Semantics

Type Source Name
disease MESH Metastasis
pathway BSID Melanoma
disease MESH melanoma
disease DOID melanoma
disease MESH development
gene UNIPROT SF3B1
gene UNIPROT SF3B2
gene UNIPROT EIF1AX
gene UNIPROT MAGI1
gene UNIPROT RNF2
gene UNIPROT BAP1
disease MESH malignancy
disease MESH Uveal Melanoma
disease DOID Uveal Melanoma

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