Mapping the protein-protein and genetic interactions of cancer to guide precision medicine.

Mapping the protein-protein and genetic interactions of cancer to guide precision medicine.

Publication date: Jul 06, 2019

Massive efforts to sequence cancer genomes have compiled an impressive catalogue of cancer mutations, revealing the recurrent exploitation of a handful of ‘hallmark cancer pathways’. However, unraveling how sets of mutated proteins in these and other pathways hijack pro-proliferative signaling networks and dictate therapeutic responsiveness remains challenging. Here, we show that cancer driver protein-protein interactions are enriched for additional cancer drivers, highlighting the power of physical interaction maps to explain known, as well as uncover new, disease-promoting pathway interrelationships. We hypothesize that by systematically mapping the protein-protein and genetic interactions in cancer-thereby creating Cancer Cell Maps-we will create resources against which to contextualize a patient’s mutations into perturbed pathways/complexes and thereby specify a matching targeted therapeutic cocktail.

Open Access PDF

Bouhaddou, M., Eckhardt, M., Chi Naing, Z.Z., Kim, M., Ideker, T., and Krogan, N.J. Mapping the protein-protein and genetic interactions of cancer to guide precision medicine. 04967. 2019 Curr Opin Genet Dev (54):

Concepts Keywords
Cancer Biophysics
Cocktail Systems biology
Genetic Interactions Biotechnology
Precision Medicine Branches of biology
Protein Disease
Protein–protein interaction
Proteomics
Signal transduction

Semantics

Type Source Name
gene UNIPROT MAGEE1
disease DOID carcinoma
disease MESH carcinoma
gene UNIPROT EPHB2
gene UNIPROT MAPK1
gene UNIPROT COL17A1
gene UNIPROT FBXW7
gene UNIPROT HRAS
gene UNIPROT PIK3CA
gene UNIPROT KRAS
drug DRUGBANK Coenzyme M
gene UNIPROT THOP1
disease MESH death
gene UNIPROT SGSM3
drug DRUGBANK L-Phenylalanine
pathway BSID Breast cancer
disease DOID breast cancer
disease MESH breast cancer
drug DRUGBANK Pentaerythritol tetranitrate
gene UNIPROT ADA2
drug DRUGBANK Imatinib
drug DRUGBANK Nonoxynol-9
drug DRUGBANK Spinosad
gene UNIPROT LARGE1
gene UNIPROT SSRP1
gene UNIPROT EHD1
gene UNIPROT RASA1
gene UNIPROT RGS6
gene UNIPROT AGL
gene UNIPROT RRAD
gene UNIPROT NAA50
disease DOID cancer
disease MESH cancer

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