MS Brain Lesions Linked to Early-life Viral Infection in Mice, Way of Blocking Inflammatory Spread Seen

MS Brain Lesions Linked to Early-life Viral Infection in Mice, Way of Blocking Inflammatory Spread Seen

Publication date: Jul 10, 2019

An experimental treatment known as OB-002, that works to block an inflammatory molecule in the brain, prevented the development of lesions there after an early-in-life viral infection in a mouse model of multiple sclerosis (MS). A research team from Switzerland and Germany found that viral infection in the brains of mice early in life, but not at a later age, worsened those MS symptoms evident in a brain, like lesions, at sites where the virus had resided but was cleared. -Early-life infection of mouse brains imprinted a chronic inflammatory signature that consisted of brain-resident memory T-cells expressing the chemokine (C-C motif) ligand 5 (CCL5),” the researchers wrote. Overall, the results showed that -transient brain viral infection early in life worsened lesion development and symptoms in a mouse model of autoimmune disease,” and that -autoimmune lesions were spatially associated with areas of previous viral infection in mice,” the researchers wrote.

Concepts Keywords
Autoimmune Chronic inflammatory signature
Autoimmune Disease Viral infections
Autoimmune Disorders Autoimmune disorders
Autoimmunity Virus infection
Brain Autoimmune disease
CCL5 Infection CCL5
CCR5 MS
CD4 Epidemiological diseases
Central Nervous System MS Sites infection
Chemokine Branches of biology
Chemokine Receptor Medical specialties
Drug Discovery Organ systems
Epidemiological Cytokines
Geneva Chemokine receptors
Germany Multiple sclerosis
Infection CCR5
Lesion CCL5
Ligand Myelin
Memory T cell
Memory T Cells CC chemokine receptors
Metabolism Drug discovery
Mice Biotechnology
Microglia
Molecule
Motif
Multiple Sclerosis
Myelin
Nerve
Pathology
RANTES
Receptor
Switzerland
T Cells
The Brain
Viral
Viral Infection
Virus

Semantics

Type Source Name
disease MESH Viral Infection
disease DOID Viral Infection
disease MESH development
disease MESH multiple sclerosis
disease DOID multiple sclerosis
disease MESH autoimmune disease
disease DOID autoimmune disease
pathway BSID Translation
gene UNIPROT CD4
disease MESH infection
gene UNIPROT CCL5
gene UNIPROT CXCR1
gene UNIPROT CCR5
disease MESH autoimmunity
pathway BSID Release

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