No Association between Smoking and Sentinel Lymph Node Metastasis and Survival in Cutaneous Melanoma.

No Association between Smoking and Sentinel Lymph Node Metastasis and Survival in Cutaneous Melanoma.

Publication date: Jul 08, 2019

There is little evidence that smoking is associated with metastasis in patients with cutaneous melanoma.

Using a propensity score matching analysis, we assessed whether smoking was associated with a higher rate of sentinel lymph node (SLN) metastasis and worse survival in these patients.

Retrospective cohort study at a referral hospital for melanoma. We studied 762 patients with known smoking status from the melanoma database of the Instituto Valenciano de OncologcEDa who underwent SLN biopsy between January 1, 2000 and December 31, 2016. The patients were matched by smoking status. The matching procedure was implemented using three logistic regression models featuring never vs former smokers, never vs current smokers, and former vs current smokers. The study outcomes were disease-free survival (DFS), melanoma-specific survival (MSS), overall survival (OS), and SLN status.

The following groups were formed based on the propensity matching scores: 114 pairs of smokers vs never smokers, 113 pairs of smokers vs former smokers, and 174 pairs of never smokers vs former smokers. Smoking status was not associated with SLN metastasis or with DFS, MSS, or OS in any of the three groups.

Smoking does not influence SLN metastasis or survival in patients with cutaneous melanoma. This article is protected by copyright. All rights reserved.

Tejera-Vaquerizo, A., Descalzo-Gallego, M.A., , Traves, Requena, C., , Bolumar, Pla, A., and Nagore, E. No Association between Smoking and Sentinel Lymph Node Metastasis and Survival in Cutaneous Melanoma. 23317. 2019 J Eur Acad Dermatol Venereol.

Concepts Keywords
Biopsy Survival DFS melanoma
Cohort Status melanoma
DFS Medicine
Logistic Regression Medical specialties
Melanoma Clinical medicine
Metastasis Oncology
Referral Hospital Cancer
Sentinel Lymph Node Melanoma
SLN RTT
Smoking Sentinel lymph node
Lymph node biopsy
Metastasis

Semantics

Type Source Name
gene UNIPROT SIL1
disease MESH smokers
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
gene UNIPROT SLN
disease DOID Cutaneous Melanoma
disease MESH Metastasis

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *