Optical Spectroscopy as a Method for Skin Cancer Risk Assessment.

Optical Spectroscopy as a Method for Skin Cancer Risk Assessment.

Publication date: Jul 09, 2019

Skin cancer is the most prevalent cancer, and its assessment remains a challenge for physicians. This study reports the application of an optical sensing method, elastic scattering spectroscopy (ESS), coupled with a classifier that was developed with machine learning, to assist in the discrimination of skin lesions that are concerning for malignancy. The method requires no special skin preparation, is non-invasive, easy to administer with minimal training, and allows rapid lesion classification. This novel approach was tested for all common forms of skin cancer. ESS spectra from a total of 1307 lesions were analyzedin a multi-center, non-randomized, clinical trial. The classification algorithm was developed on a 950-lesion training dataset, and its diagnostic performance was evaluated against a 357-lesion testing dataset that was independent of the training dataset. The observed sensitivity was 100% (14/14) for melanoma and 94% (105/112) for non-melanoma skin cancer. The overall observed specificity was 36% (84/231). ESS has potential, as an adjunctive assessment tool, to assist physicians to differentiate between common benign and malignant skin lesions. This article is protected by copyright. All rights reserved.

Rodriguez-Diaz, E., Manolakos, D., Christman, H., Bonning, M.A., Geisse, J.K., A’Amar, O.M., Leffell, D.J., and Bigio, I.J. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. 23321. 2019 Photochem Photobiol.

Concepts Keywords
Algorithm Lesion
Benign Cancer
Cancer Clinical medicine
Classifier Health
Discrimination RTT
Elastic Scattering Melanoma
Lesion Medicine
Malignancy Prevalent cancer
Malignant Optical sensing
Melanoma Spectroscopy
Optical Sensing
Randomized Clinical Trial
Skin Cancer


Type Source Name
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
disease MESH multi
disease DOID ESS
disease DOID cancer
disease MESH cancer
disease DOID Skin Cancer
disease MESH Skin Cancer


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