VIPdb, a genetic Variant Impact Predictor Database.

VIPdb, a genetic Variant Impact Predictor Database.

Publication date: Jul 08, 2019

Genome sequencing identifies vast number of genetic variants. Predicting these variants’ molecular and clinical effects is one of the preeminent challenges in human genetics. Accurate prediction of the impact of genetic variants improves our understanding of how genetic information is conveyed to molecular and cellular functions, and is an essential step towards precision medicine. Over one hundred tools/resources have been developed specifically for this purpose. We summarize these tools as well as their characteristics, in the genetic Variant Impact Predictor Database (VIPdb). This database will help researchers and clinicians explore appropriate tools, and inform the development of improved methods. This article is protected by copyright. All rights reserved.

Hu, Z., Yu, C., Furutsuki, M., Andreoletti, G., Ly, M., Hoskins, R., Adhikari, A.N., and Brenner, S.E. VIPdb, a genetic Variant Impact Predictor Database. 04964. 2019 Hum Mutat.

Concepts Keywords
Genetic Branches of biology
Genetics Genetics
Precision Medicine Molecular biology
Sequencing Bioinformatics
Genomics
Classical genetics
DNA
Phenotype
Whole genome sequencing
Genotype-first approach
Genotype

Semantics

Type Source Name
disease MESH development
gene UNIPROT PTPN5
gene UNIPROT IMPACT

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