Evaluation of oxidative stress mechanisms and the effects of phytotherapic extracts on Parkinson’s disease Drosophila PINK1 model.

Evaluation of oxidative stress mechanisms and the effects of phytotherapic extracts on Parkinson’s disease Drosophila PINK1 model.

Publication date: Jul 10, 2019

Oxidative stress is commonly observed in both idiopathic and genetic cases of Parkinson’s disease (PD). It plays an important role in the degeneration of dopaminergic neurons, and it has been associated with altered telomere length (TL). There is currently no cure for PD, and extracts of antioxidative plant, such as Mucuna pruriens and Withania somnifera, are commonly used in Ayurveda to treat patients with PD. In this study, we evaluated 2 enzymatic markers of oxidative stress, glutathione (GSH) system and superoxide dismutase (SOD), and TL in a Drosophila melanogaster model for PD [phosphatase and tensin homolog-induced putative kinase 1 (PINK1) ]. This evaluation was also performed after treatment with the phytoextracts. PINK1 mutants showed a decrease in GSH amount and SOD activity and unexpected longer telomeres compared with wild-type flies. M. pruriens treatment seemed to have a beneficial effect on the oxidative stress conditions. On the other hand, W. somnifera treatment did not show any improvements in the studied oxidative stress mechanisms and even seemed to favor the selection of flies with longer telomeres. In summary, our study suggests the importance of testing antioxidant phytoextracts in a PINK1 model to identify beneficial effects for PD.-Baroli, B., Loi, E., Solari, P., Kasture, A., Moi, L., Muroni, P., Kasture, S., Setzu, M. D., Liscia, A., Zavattari, P. Evaluation of oxidative stress mechanisms and the effects of phytotherapic extracts on Parkinson’s disease Drosophila PINK1 model.

Baroli, B., Loi, E., Solari, P., Kasture, A., Moi, L., Muroni, P., Kasture, S., Setzu, M.D., Liscia, A., and Zavattari, P. Evaluation of oxidative stress mechanisms and the effects of phytotherapic extracts on Parkinson’s disease Drosophila PINK1 model. 21561. 2019 FASEB J.

Concepts Keywords
Antioxidant Senescence
Antioxidative Chromosomes
Ayurveda Molecular biology
Dopaminergic Cell biology
Drosophila PINK1
Drosophila Melanogaster Antioxidants
Enzymatic Proteins
FASEB Branches of biology
Genetic Enzymes
Glutathione Parkin
Homolog Oxidative stress
Idiopathic Telomere
Kinase
Mutants
Neurons
Oxidative Stress
Parkinson
Phosphatase
PINK1
Superoxide Dismutase
Telomere
Telomeres
TL
Wild Type
Withania Somnifera

Semantics

Type Source Name
gene UNIPROT SOD1
disease DOID SOD
drug DRUGBANK Glutathione
gene UNIPROT PINK1
pathway BSID Oxidative Stress
disease MESH oxidative stress

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