Publication date: Jul 13, 2019
Biodegradable lipid nanoparticles deliver mRNA coding for the gene editing molecules into the cell Credit: From animation by Visual Science and Skoltech, visual-science.
The delivery uses biodegradable synthetic lipid nanoparticles that carry the molecular editing tools into the cell to precisely alter the cells’ genetic code with as much as 90 percent efficiency.
The nanoparticles represent one of the most efficient CRISPR/Cas9 delivery tools reported so far, according to the researchers, and could help overcome technical hurdles to enable gene editing in a broad range of clinical therapeutic applications.
Upon entering the cell, in vitro or in vivo, the linkers are broken and the particles disintegrate for delivery of contents and translation of mRNA into active enzyme for CRISPR/Cas9 genome editing Credit: Qiaobing Xu, Tufts University “We are just starting to see human clinical trials for CRISPR therapies,” said Qiaobing Xu, co-corresponding author of the study and associate professor of biomedical engineering at Tufts University.
information: Ji Liu et al, Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles, Advanced Materials (2019).
DOI: Citation: Novel nanoparticles deliver CRISPR gene editing tools into the cell with much higher efficiency (2019, July 12) retrieved 13 July 2019 from This document is subject to copyright.
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