Publication date: Jul 12, 2019
This post was originally published on this site The use of gadodiamide, a gadolinium-based contrast agent (GBCA) often used to help clinicians visualize brain structures in magnetic resonance imaging (MRI) scans, leads to the accumulation of gadolinium in certain regions of multiple sclerosis (MS) patients’ brains early in the course of the disease, a study has found. Those findings, in the study -Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS,” were published recently in Neurology, the medical journal of the American Academy of Neurology (AAN). Results showed that at follow-up, almost half of the MS patients (49. 3%) had areas of high-gadolinium intensity in the dentate nucleus (a brain region responsible for controlling voluntary movements and cognition), while none of the controls had the same type of high-intensity gadolinium depositions in the same region. -Therefore, we cannot completely rule out that gadolinium deposition may have an impact on disease progression or clinical outcome,” Zivadinov said, adding that the findings from the study -should be incorporated into a risk-versus-benefit analysis when determining the need for GBCA administration in individual MS patients. ” The post Study Examines Gadolinium Deposits in MS Patients’ Brains, But Still Can’t Determine Relationship with Disease Severity appeared first on Multiple Sclerosis News Today. The post Study Examines Gadolinium Deposits in MS Patients’ Brains, But Still Can’t Determine Relationship with Disease Severity appeared first on BioNewsFeeds.
- Gadolinium deposition occurs in early multiple sclerosis
- Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS.
- Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis.
- GBCA-enhanced MRI does not influence MS progression
- Decrease in secondary neck vessels in multiple sclerosis: A 5-year longitudinal magnetic resonance angiography study.