Publication date: Jul 09, 2019
CD8 T cells can kill malignant cells in an antigen-specific manner. However, anti-tumoral responses are usually limited by suppressive factors that curb the effector responses of tumor-infiltrating CD8 T cells. Therapeutic strategies to overcome intra-tumoral T cell suppression, for example immune checkpoint inhibition, have been clinically effective in patients with cancer. Here, we provide data that demonstrates that GK-1, a peptide derived from the parasite Taenia crassiceps, promotes an anti-melanoma CD8 T cell response with heightened effector characteristics that leads to an increased amount of tumor-infiltrating CD44 IFN-γ-producing CD8 T cells. The response induced by GK-1 was associated with a reduction in the expression of PD-1 and PD-L1 on tumor-infiltrating CD8 and dendritic cells, respectively, effects that led to a dramatic decrease in tumor burden. Our results suggest that the immunomodulatory properties of GK-1 may promote a CD8 T cell response that may be therapeutically useful in the setting of cancer.
Rodr’iguez-Rodr’iguez, N., Madera-Salcedo, I.K., Bugarin-Estrada, E., S’anchez-Miranda, E., Torres-Garc’ia, D., Cervantes-Torres, J., Fragoso, G., Rosetti, F., Crisp’in, J.C., and Sciutto, E. The helminth-derived peptide GK-1 induces an anti-tumoral CD8 T cell response associated with downregulation of the PD-1/PD-L1 pathway. 23356. 2019 Clin Immunol.
- Combination of pentoxifylline and α-galactosylceramide with radiotherapy promotes necro-apoptosis and leukocyte infiltration and reduces the mitosis rate in murine melanoma.
- Vulvar melanoma: management of primary disease and repeated recurrences.
- Antitumor effect of chiral organotelluranes elicited in a murine melanoma model.
- Melanogenic inhibitory effects of Triangularin in B16F0 melanoma cells, in vitro and molecular docking studies.
- Anti-worm drug inhibits tumor growth and spread in mice
- Survival analysis and sentinel lymph node status in thin cutaneous melanoma: A multicenter observational study.