Cdk5 Protein Activity in Brain Linked to Depression, Potentially Even Treatment, in Huntington’s, Mouse Study Suggests

Cdk5 Protein Activity in Brain Linked to Depression, Potentially Even Treatment, in Huntington’s, Mouse Study Suggests

Publication date: Jul 25, 2019

This post was originally published on this site Differences in the activity of a protein called Cdk5 in the brain could be a cause of – and perhaps even a target for the treatment of – depression related to Huntington’s disease, research in mice suggests. In analyzing the mice’s brains, the researchers found that Cdk5 activity was higher in the nucleus accumbens and the prefrontal cortex – two regions of the brain associated with, among other things, depression. For example, the mice treated with the Cdk5 blocker were quicker to move in stress tests than mice given a placebo – although it should be noted that the treated mice with Huntington’s still showed more depression-like symptoms than mice without the disease. Importantly, when the researchers engineered Huntington’s mice with a version of DARPP-32 that could no longer be phosphorylated by Cdk5, the mice no longer had depression-like symptoms. These data suggest that preventing this specific molecular event – the phosphorylation of DARPP-32 by Cdk5 – could be a feasible strategy for preventing and treating depression in people with Huntington’s.

Concepts Keywords
Antidepressants Energy
Anxiety Cognitive disorders
Atom JournalBiological Psychiatry Depression
Barcelona Cdk5 longer depression
Brain Medicine severe depression
Cognition Branches of biology
Cognitive Cellular processes
Cyclin Dependent Kinase Cell cycle
Depression Cell biology
Energy Cyclin-dependent kinase 5
Enzyme Proteins
Huntington Addiction
Kinase PPP1R1B
Medicine Major depressive disorder
Molecule Nucleus accumbens
Nucleus Accumbens Methamphetamine
Oxygen
Phenotype
Phenotypes
Phosphate
Phosphorus
Phosphorylate
Phosphorylated
Phosphorylation
Placebo
Prefrontal Cortex
Stress

Semantics

Type Source Name
gene UNIPROT CDK5
disease MESH Depression
gene UNIPROT SLC35G1
gene UNIPROT PPP1R1B
gene UNIPROT SSRP1
disease MESH development
disease MESH anxiety
disease DOID anxiety
pathway BSID Release
drug DRUGBANK Oxygen
drug DRUGBANK Tropicamide

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *