Cerebral Blood Flow and tDCS

Cerebral Blood Flow and tDCS

Publication date: Jul 25, 2019

With this study, the investigators will substantiate if regional cerebral blood flow (CBF) is affected by tDCS, assess the amount of CBF change in relation to different currents, and measure differences in regional CBF under stimulation reactivity between healthy subjects and people with Multiple Sclerosis (PwMS)using Water O-15 PET (Water Oxygen-15 Positron EmissionTomography) imaging. The objective is to investigate the changes in regional CBF after transcranial direct current stimulation (tDCS) at different intensities (1 mA, 2 mA, 3 mA, 4 mA) in healthy subjects and PwMS. The design is a cross-sectional proof of principle study in 10 healthy subjects and 10 PwMS. Relative regional brain CBF (rCBF) will be analyzed semi-quantitatively using voxel-wise and region of interest-based approaches. Changes in CBF associated with tDCS-application will be calculated with a general linear model in a ramp function of the task-specific rCBF, according to previous work in our group using a glucose analogue. Exploratory statistical testing will be done using a paired samples t-test between task and rest conditions and unpaired t-tests between PwMS and healthy controls at the same intensities. With this study the investigators will be able to dose-dependently measure real-time rCBF changes after non-invasively stimulating the superficial parts of the dorsolateral prefrontal cortex (DLPFC), a commonly used target in therapeutic tDCS applications. This will provide further insight into whether tDCS is capable of inducing changes in rCBF.

Concepts Keywords
Aim Neurotechnology
Aneurysm Medical devices
Bed Rest Neurophysiology
Brain Electrotherapy
CBF Neurostimulation
Cerebral Blood Flow Clinical medicine
Claustrophobia Branches of biology
Cochlear Implant Medicine
Cognitive Bed rest
Consciousness Subjects experienced stroke
Contraindication Cochlear implant
Cortex Injuries
Cortical Specific medication disease
Coupling Min headaches
Cross Aneurysm
Disability Safety protocol
Dorsolateral Prefrontal Cortex Imaging
Drug Abuse Broader networks
Electrode Real time rCBF
Electrodynamics Stimulation protocol
Empirical Evidence Metal clips wires
Energy G metal shavings
FMRI Transcranial direct-current stimulation
Foreign Body Cerebral circulation
Functional Magnetic Resonance Brain stimulation
General Linear Safety protocol
Glucose Magnetic resonance Imaging
Hydrocephalus Stimulation protocol
Infusion
Iowa
Itching
Magnetic Field
Magnitude
Mechanics
Metabolism
Modality
Motor Evoked Potentials
Multiple Sclerosis
Neurologist
Oxidative Phosphorylation
Oxygen
Pacemaker
Perfusion
PET
Protocol
Questionnaire
Radiofrequency
RCBF
Stroke
TDCS
Telephone
Traumatic Brain Injury
Voxel

Semantics

Type Source Name
gene UNIPROT KCNK3
gene UNIPROT PAMR1
gene UNIPROT DTL
gene UNIPROT ZMYM2
disease MESH ramp
drug DRUGBANK Oxygen
drug DRUGBANK Water
disease DOID Multiple Sclerosis
disease MESH Multiple Sclerosis
gene UNIPROT CEBPZ
disease MESH Cerebral Blood Flow
disease DOID hydrocephalus
disease MESH hydrocephalus
disease MESH drug abuse
gene UNIPROT FBN1
gene UNIPROT EHD1
disease MESH diagnosis
gene UNIPROT REST
drug DRUGBANK D-glucose
drug DRUGBANK Dextrose unspecified form
disease MESH Claustrophobia
disease MESH contraindication
gene UNIPROT MAGEE1
disease MESH Aneurysm
gene UNIPROT CLIP2
gene UNIPROT POMC
gene UNIPROT CLIP1
disease MESH foreign body
gene UNIPROT NR4A2
gene UNIPROT ALG3
disease MESH Sclerosis

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