Comparison of seventh and eighth edition of AJCC staging system in melanomas at locoregional stage.

Comparison of seventh and eighth edition of AJCC staging system in melanomas at locoregional stage.

Publication date: Jul 25, 2019

The eighth edition of the American Joint Committee on Cancer (AJCC) staging system has been effective since January 2018. It has introduced some major changes in the localized/locoregional melanoma classification. However, it has not been demonstrated how this classification was validated on external, clinical data.

In this retrospective study, we have included 2474 patients diagnosed with cutaneous melanoma in localized or locoregional stage. They were treated surgically in our Center between years 1998 and 2014. Melanoma-specific and overall survival were calculated for each stage according to TNM7 and TNM8 using Kaplan-Meier estimator.

The melanoma-specific survival rates in our patients were similar to those reported from original cohort used to build TNM8 classification except for stage IIIC (5-year melanoma-specific survival 44.6% vs 51.8%, respectively for TNM7 vs TNM8).

Our study validated the eighth edition of TNM melanoma staging system as a viable tool in prognosis of the long-term survival of patients with localized or locoregionally advanced melanoma on an independent cohort. The new TNM 8 system has brought important improvements in prognostic assessment for melanoma patients. Deeper understanding of the significance of satellite/in-transit lesions may be required.

Teterycz, P., , Lugowska, Kosela-Paterczyk, H., and Rutkowski, P. Comparison of seventh and eighth edition of AJCC staging system in melanomas at locoregional stage. 23508. 2019 World J Surg Oncol (17):1.

Concepts Keywords
Cohort Significance satellite
Estimator Cutaneous melanoma
Melanoma Edition TNM melanoma
Melanomas Localized locoregional melanoma
Prognosis Years Melanoma
Satellite Medicine
TNM Health
TNM System Clinical medicine
Transit Melanoma
Cancer staging
AJCC staging system
Breslow’s depth
TNM staging system

Semantics

Type Source Name
gene UNIPROT TENM1
disease DOID cutaneous melanoma
pathway BSID Melanoma
disease DOID melanoma
disease DOID Cancer
disease MESH Cancer
disease MESH melanomas

Original Article

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