An Expansion of the Cognition-Mood Relationship Model in Multiple Sclerosis

An Expansion of the Cognition-Mood Relationship Model in Multiple Sclerosis

Publication date: Jul 31, 2019

Specific cognitive functions, such as nonverbal memory and attention/processing speed, are linked to specific mood profiles, such as anxiety and depression, in patients with multiple sclerosis (MS) according to a recent article published in the Multiple Sclerosis Journal.

Using correlation analysis of the cognitive assessment tasks, in addition to the anxiety and depression levels of the patients, researchers found in both cohorts lower anxiety levels were associated with better nonverbal memory (RADIEMS rp=-. 220, P =. 003; MEM CONNECT rp=-. 271, P =. 028).

The researchers concluded that the consistency between the 2 cohorts evaluated establishes a step toward a more precise cognition-mood relationship model in patients with MS. They believe these findings support links of anxiety and depression to specific, objectively measured cognitive functions rather than linking them to worsening of mood to general or overall worsening of cognition.

Concepts Keywords
Anxiety Depression
Cognition Anxiety
Cognitive Major depressive disorder
Cohort Multiple sclerosis
Correlation Magnetic resonance imaging
Cross Mood disorders
Depression Abnormal psychology
Fatigue Psychiatric diagnosis
Lesion Psychiatry
Magnetic Resonance Imaging Emotions
Memory Human behavior
Multiple Sclerosis Psychology
Neuropsychological Fatigue
Phenotypes Further lower depression

Semantics

Type Source Name
gene UNIPROT PTPN5
disease DOID Multiple Sclerosis
disease MESH anxiety
disease DOID anxiety
disease MESH depression
drug DRUGBANK Methylergometrine
disease DOID relapsing-remitting MS
drug DRUGBANK Tropicamide
disease MESH cognitive decline
disease MESH Multiple Sclerosis

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