Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy.

Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy.

Publication date: Jul 30, 2019

T regulatory cells (Tregs) are an important T cell population for immune tolerance, prevention of autoimmune diseases and inhibition of antitumor immunity. The tumor-promoting role played by Tregs in cancer has prompted numerous approaches to develop immunotherapeutics targeting Tregs. One approach to depletion of Treg cells is retargeting the highly potent cytotoxic activity of bacterial toxins. These agents capitalize on the well-characterized bacterial toxins, diphtheria toxin and Pseudomonas aeruginosa exotoxin A-both of which harbor membrane translocation domains and enzymatic domains that catalytically halt protein synthesis within intoxicated eukaryotic cells and act at picomolar or subpicomolar concentrations. In this review, we summarize the preclinical and clinical development of several Treg-depleting cancer immunotherapies based on these two bacterial toxins.

Kumar, P., Kumar, A., Parveen, S., , Murphy, and Bishai, W. Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy. 23531. 2019 Immunotherapy.

Concepts Keywords
Autoimmune Diseases Pseudomonas
Cytotoxic Melanoma
Diphtheria Toxin Bacterial toxins diphtheria
Enzymatic Immunotherapy
Eukaryotic Anticancer therapy
Immune Tolerance Immunotherapies
Immunity Branches of biology
Immunotherapeutics Bacterial toxins
Immunotherapies Microbiology
Immunotherapy T cells
Membrane Diphtheria toxin
Picomolar Microbial toxin
Pseudomonas Aeruginosa Pseudomonas exotoxin
Translocation Regulatory T cell
Treg Denileukin diftitox
Tregs Immunotherapeutics
Tumor

Semantics

Type Source Name
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
drug DRUGBANK Denileukin diftitox
disease MESH development
disease DOID diphtheria
disease MESH diphtheria
disease MESH autoimmune diseases
disease MESH immune tolerance
disease DOID cancer
disease MESH cancer

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