Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic Neuritis

Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic Neuritis

Publication date: Aug 01, 2019

In light of experimental models showing that neuronal electrical activity is crucial for the remyelination process, we hypothesize that maintenance of electrical axonal activity in the early stages of optic neuritis may promote myelin repair, limiting thereby axonal degeneration. In humans, electrical stimulation of the optic nerve has been tested mainly in ischemic neuropathy and retinitis pigmentosa, which are both associated with severe axonal/retinal pathology and poor visual prognosis. In contrast, the inflammation of the optic nerve in optic neuritis is generally transient, with less severe axonal damage at the acute phase, which would allow for better efficacy of electrical stimulation as a strategy to promote remyelination and neuroprotection.In light of experimental models showing that neuronal electrical activity is crucial for the remyelination process, we hypothesize that maintenance of electrical axonal activity in the early stages of optic neuritis may promote myelin repair, limiting thereby axonal degeneration. In humans, electrical stimulation of the optic nerve has been tested mainly in ischemic neuropathy and retinitis pigmentosa, which are both associated with severe axonal/retinal pathology and poor visual prognosis. In contrast, the inflammation of the optic nerve in optic neuritis is generally transient, with less severe axonal damage at the acute phase, which would allow for better efficacy of electrical stimulation as a strategy to promote remyelination and neuroprotection.

Concepts Keywords
Bolus MS
CIS Acute Optic Neuritis
Corticosteroids Plasma exchanges
Electrophysiology Organ systems
Inflammation Nervous system
Ischemic Neuroscience
Magnetoencephalography Autoimmune diseases
MEG Optic neuritis
MRI Neurological disorders
Multiple Sclerosis Neurotechnology
Myelin Myelin
Nerve Optic nerve
Neuritis Neuromodulation
Neurological Multiple sclerosis
Neuropathy MRI
Neuroprotection
Ophthalmological
Optic Nerve
Optic Neuritis
Pathology
Placebo
Plasma
Prognosis
Retinal
Retinitis Pigmentosa
Visual Acuity

Semantics

Type Source Name
disease MESH Optic Neuritis
disease DOID Optic Neuritis
gene UNIPROT TNFSF14
disease DOID ischemic neuropathy
disease MESH retinitis pigmentosa
disease DOID retinitis pigmentosa
disease MESH visual
disease MESH inflammation
gene UNIPROT MAGEE1
drug DRUGBANK Tropicamide
gene UNIPROT RENBP
disease MESH Syndrome
disease DOID Syndrome
gene UNIPROT CISH
gene UNIPROT TBATA
gene UNIPROT CYREN
disease MESH Sclerosis
drug DRUGBANK Diethylstilbestrol
gene UNIPROT DES

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *