A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment.

A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment.

Publication date: Aug 01, 2019

Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose of melanoma cells through of 5-lipoxygenase inflammatory pathway and its product leukotriene B and also that the peritumoral treatment with eicosapentaenoic acid and its product, leukotriene B, reduces the tumor development, the effect of the treatment by gavage with omega-3 and omega-6 in the tumor microenvironment favorable to melanoma growth associated with acute inflammation has never been studied.

C57BL/6 mice were coinjected with 1 cD7 10 apoptotic cells plus 1 cD7 10 viable melanoma cells into the subcutaneous tissue and treated by gavage with omega-3-rich fish oil or omega-6-rich soybean oil or a mixture of these oils (1:1 ratio) during five consecutive days.

The treatment by gavage with a mixture of fish and soybean oils (1:1 ratio) both reduced the melanoma growth and the levels of leukotriene B (LTB), prostaglandin E (PGE), PGE/prostaglandin E (PGE) ratio, and CXC ligand 1 (CXCL1) and increased the levels of interleukin 10 (IL-10) to IL-10/CXCL1 ratio in the melanoma microenvironment.

The oral administration of a 1:1 mixture of fish oil and soybean oil was able to alter the release of inflammatory mediators that are essential for a microenvironment favorable to the melanoma growth in mice, whereas fish oil or soybean oil alone was ineffective.

Concepts Keywords
Apoptotic Inflammation
Eicosapentaenoic Acid Omega-3 fatty acid
Fish CXCL1
Fish Oil Leukotriene
Gavage Omega-6 fatty acid
Inflammation Immunology
Inflammatory Mediators Eicosanoids
Interleukin Fatty acids
Leukotriene Branches of biology
Ligand Medicine
Lipoxygenase Health
Melanoma CXCL1 ratio melanoma
Mice Acute inflammation
Microenvironment Tumor
Prostaglandin Favorable melanoma
Sci Fish oil omega
Soybean
Soybean Oil
Subcutaneous Tissue
Tumor
Tumorigenic

Semantics

Type Source Name
gene UNIPROT LOX
gene UNIPROT CPOX
gene UNIPROT IL10
pathway BSID Release
drug DRUGBANK Interleukin-10
gene UNIPROT CXCL1
gene UNIPROT LTB
gene UNIPROT SH3PXD2A
drug DRUGBANK Soybean oil
drug DRUGBANK Fish oil
drug DRUGBANK Omega-3 fatty acids
drug DRUGBANK Icosapent
gene UNIPROT ALOX5
disease MESH inflammation
disease MESH Tumor
disease MESH Growth
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma
pathway BSID Fatty acids

Original Article

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