A comparative study on the biological activity of essential oil and total hydro-alcoholic extract of Satureja hortensis L.

A comparative study on the biological activity of essential oil and total hydro-alcoholic extract of Satureja hortensis L.

Publication date: Aug 01, 2019

Satureja hortensis L. presents an increased interest due to its chemical composition, abundant in monoterpenes, aglyconic and glycosylates flavonoids, and phenolic acids, leading to important biological activity. The present study compared the biological activity of volatile oil (VO) and total hydro-alcoholic extract (TE) of Satureja hortensis L. in terms of: i) antioxidant activity; ii) antimicrobial activity; and iii) viability, migration and proliferation on two healthy cell lines (keratinocytes-HaCaT and fibroblasts-1BR3) and two melanoma cell lines (human-A375 and murine-B164A5). Antioxidant activity of VO and TE showed maximal values around 72%. Antimicrobial screening highlighted the inhibitory capacity of VO against all seven tested bacteria strains, with the most pronounced effect against S. aureus and C. albicans, while TE exerted only a slight activity against three bacteria strains. VO showed greater efficacy than TE on both tumor cell lines (A375 and B164A5), the activity of the compounds was higher when low concentrations were used (5, 10 and 25 uM) while at high concentrations (50 and 100 uM) the percentages of viability were increased.

Open Access PDF

Popovici, R.A., Vaduva, D., , Pinzaru, Dehelean, C.A., Farcas, C.G., Coricovac, D., Danciu, C., , Popescu, Alexa, E., , Lazureanu, and Stanca, H.T. A comparative study on the biological activity of essential oil and total hydro-alcoholic extract of Satureja hortensis L. 23651. 2019 Exp Ther Med (18):2.

Concepts Keywords
Antimicrobial Total extract melanoma
Antioxidant Greater efficacy tumor
Bacteria Satureja
Biological Activity Lamiaceae
Essential Oil Herbs
Fibroblasts
Flavonoids
Keratinocytes
Melanoma
Monoterpenes
Murine
Phenolic Acids
Tumor
Volatile Oil

Semantics

Type Source Name
disease MESH tumor
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *