Alternating DBS for Stepping Control in Parkinson’s Disease

Alternating DBS for Stepping Control in Parkinson’s Disease

Publication date: Aug 06, 2019

Parkinson’s disease (PD) is a disabling, progressive condition characterised by severe problems with movement for which medical treatment in the longer term can be unsatisfactory. Deep brain stimulation (DBS) is a treatment, which directly stimulates the nerve cells affected inside the brain to help overcome the difficulties with movement. Classically, DBS stimulates in a manner that is constant. Many patients develop severe problems with walking, so-called freezing of gait, which can be unresponsive to constant DBS. In this study the investigators will test if left-right alternating DBS helps to improve gait problems by potentially promoting left-right alternating up- and down-modulated brain activity, which was found during walking in a previous study. The investigators will test if alternating DBS improves the ability to adjust walking speed and to walk freely compared to constant DBS.

Concepts Keywords
Brain Deep brain stimulation
Cognitive Medicine
Cognitive Impairment Clinical medicine
DBS Medical specialties
Deep Brain Stimulation Neurotechnology
Gait Electrotherapy
Nerve Medical devices
Oxford Neurosurgical procedures
Parkinson Deep brain stimulation
Progressive Tourette syndrome
Subthalamic Nucleus Subthalamic nucleus
DBS

Semantics

Type Source Name
disease MESH gait
disease MESH Cognitive impairment
gene UNIPROT KCNK3
disease MESH Parkinson Disease
disease DOID Parkinson Disease

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