Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

Publication date: Aug 07, 2019

This is a multi-center prospective rater-masked (blinded) randomized controlled trial of 156 participants, comparing the treatment strategy of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) to the treatment strategy of Best Available Therapy (BAT) for treatment-resistant relapsing multiple sclerosis (MS). Participants will be randomized at a 1 to 1 (1:1) ratio. All participants will be followed for 72 months after randomization (Day 0, Visit 0).

Concepts Keywords
Alanine
Alemtuzumab
ALT
Anemia
Antibody
Antifungals
Antiparasitic
Antivirals
Aortic Valve
Arrhythmia
Artery
AST
Autoimmune
Autologous
Basal
Beta Blocker
Bilirubin
Blood
Body Form
Bone Marrow
Brain
Bronchodilator
Carbon Monoxide
Carcinoma
Cerebrospinal Fluid
Cervix
Chemotherapy
Cirrhosis
CKD
Cladribine
Congestive Heart Failure
Connective Tissue
Contraindication
Cytopenia
Demyelination
Dermatomyositis
Diabetes Mellitus
DMT
EGFR
Ejection Fraction
Encephalomyelitis
Endoparasitic
Erythematous
Exertional Angina
FDA
FEV1
Fingolimod
Formula
Fungal Infection
Gadolinium
Glomerular Filtration Rate
HbA1c
Heart Valve Disease
Hematopoietic
Hemoglobinopathy
Hepatitis
HIV
IM
Immune Cells
Immune System
Immunization
Immunosuppression
Infection
Informed Consent
Infusion
Intravenous
Lesion
Leukocytosis
Live Attenuated Vaccines
Lungs
Lupus
LVEF
Magnetic Resonance Imaging
Malignancy
Memory
Methylprednisolone
Mitral
Mitral Valve Prolapse
MOG
Monoclonal Antibody
MRI
Multiple Sclerosis
Myelin
Myelodysplastic Syndrome
Natalizumab
Nerve
Neurologist
Neurology
Neuromyelitis Optica
Opportunistic Infections
Parenteral
PML
Polycythemia
Polymyositis
PPD
Premature Ventricular Contractions
Progressive
Progressive Multifocal Leukoencephalopathy
Prosthetic
Randomization
Randomized Controlled Trial
Relapse
Renal
Rheumatoid Arthritis
Rheumatologic
Rituximab
Sarcoidosis
Sickle
Skin Cancer
Spinal Cord
Squamous
Stem Cells
Stenosis
Syndrome
Systemic Sclerosis
Tuberculin Test
Urination
Valve
Vasculitis
Ventricular
Versus
Viral

Semantics

Type Source Name
drug DRUGBANK L-Alanine
disease DOID cirrhosis
disease MESH cirrhosis
disease MESH infection
pathway BSID Hepatitis C
disease MESH hepatitis C
disease DOID hepatitis C infection
pathway BSID Hepatitis B
disease DOID hepatitis B
disease MESH hepatitis B
gene UNIPROT EHD1
disease DOID hemoglobinopathy
disease MESH hemoglobinopathy
disease DOID sickle cell anemia
disease MESH sickle cell anemia
disease MESH leukocytosis
disease MESH thrombocythemia
disease DOID polycythemia
disease MESH polycythemia
gene UNIPROT PAFAH1B1
disease DOID MDS
disease DOID myelodysplastic syndrome
disease MESH myelodysplastic syndrome
gene UNIPROT PML
disease DOID progressive multifocal leukoencephalopathy
disease MESH progressive multifocal leukoencephalopathy
gene UNIPROT CSF2
drug DRUGBANK Methylprednisolone
disease DOID encephalomyelitis
disease MESH encephalomyelitis
gene UNIPROT MOG
disease DOID neuromyelitis optica
disease MESH neuromyelitis optica
disease DOID primary progressive Multiple Sclerosis
disease MESH primary progressive Multiple Sclerosis
disease MESH contraindication
drug DRUGBANK Gadolinium
disease MESH relapse
drug DRUGBANK Alemtuzumab
drug DRUGBANK Natalizumab
drug DRUGBANK Ocrelizumab
drug DRUGBANK Fingolimod
drug DRUGBANK Siponimod
drug DRUGBANK Daclizumab
drug DRUGBANK Cladribine
drug DRUGBANK Teriflunomide
drug DRUGBANK Dimethyl fumarate
drug DRUGBANK Rituximab
gene UNIPROT DMTN
drug DRUGBANK Dimethyltryptamine
disease MESH treatment failure
gene UNIPROT CYREN
disease MESH abnormalities
disease MESH Diagnosis
gene UNIPROT BAAT
disease MESH multi
disease DOID Multiple Sclerosis
disease MESH Multiple Sclerosis
gene UNIPROT SLC17A5
disease MESH HIV infection
disease DOID HIV infection
pathway BSID HIV Infection
drug DRUGBANK Gold
drug DRUGBANK p-Phenylenediamine
gene UNIPROT AGO2
gene UNIPROT HPD
disease MESH opportunistic infections
disease MESH invasive fungal infection
disease MESH Infectious Disease
disease DOID Infectious Disease
pathway BSID Infectious disease
disease MESH cardiac disease
disease MESH Arrhythmia
disease MESH premature ventricular contractions
disease MESH Coronary artery disease
disease DOID Coronary artery disease
disease MESH congestive heart failure
disease DOID congestive heart failure
disease MESH heart valve disease
disease DOID heart valve disease
disease MESH stenosis
disease MESH mitral valve prolapse
disease DOID mitral valve prolapse
disease MESH ventricular ejection fraction
disease MESH renal
gene UNIPROT EGFR
disease DOID CKD
gene UNIPROT TFPI
drug DRUGBANK Carbon monoxide
gene UNIPROT CYGB
disease MESH diabetes mellitus
disease DOID diabetes mellitus
disease MESH malignancy
disease MESH skin cancer
disease DOID skin cancer
disease MESH carcinoma in situ
disease MESH autoimmune disease
disease DOID autoimmune disease
disease DOID lupus
disease MESH systemic sclerosis
disease DOID systemic sclerosis
disease MESH rheumatoid arthritis
disease DOID rheumatoid arthritis
pathway BSID Rheumatoid arthritis
disease MESH syndrome
disease DOID syndrome
disease MESH polymyositis
disease MESH dermatomyositis
disease DOID dermatomyositis
disease MESH mixed connective tissue disease
disease DOID mixed connective tissue disease
disease MESH polymyalgia rheumatica
disease DOID polymyalgia rheumatica
disease MESH sarcoidosis
disease DOID sarcoidosis
disease MESH vasculitis
disease MESH vasculitis
disease DOID vasculitis
disease MESH vascular disease
disease DOID vascular disease
disease DOID active peptic ulcer disease
disease MESH duodenal ulcer
disease DOID duodenal ulcer
disease MESH sterility
disease MESH mental deficiency
disease MESH cognitive dysfunction
disease MESH hypersensitivity
disease DOID hypersensitivity
disease MESH cerebrovascular disorders
disease MESH transient ischemic attack
disease DOID transient ischemic attack
disease MESH subarachnoid hemorrhage
disease MESH cerebral hemorrhage
disease MESH neurological disorders
disease MESH spinal cord tumor
disease MESH myelopathy
disease DOID myelopathy
disease MESH comorbidity
gene UNIPROT NR4A2
gene UNIPROT ALG3
disease MESH Sclerosis

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