Do BDNF and NT-4/5 exert synergistic or occlusive effects on corticostriatal transmission in a male mouse model of Huntington’s disease?

Do BDNF and NT-4/5 exert synergistic or occlusive effects on corticostriatal transmission in a male mouse model of Huntington’s disease?

Publication date: Aug 07, 2019

Brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) are trophic factors belonging to the neurotrophin family; in addition to their trophic role, both neurotrophins play an important role in modulating corticostriatal synaptic transmission. Failures in BDNF supply and mitochondrial dysfunction are among the factors involved in the striatal degeneration that occurs in Huntington’s disease (HD). While the effects of BDNF have been widely studied in striatal degeneration, the role of NT-4/5 has been less addressed. NT-4/5 does not appear to exert effects similar to those of BDNF in HD. The physiological roles of these molecules in corticostriatal transmission have been evaluated separately, and we have demonstrated that sequential exposure to both neurotrophins results in different modulatory effects on corticostriatal transmission depending on the exposure order. In the present study, we evaluated the effects of BDNF followed by NT-4/5 or NT-4/5 followed by BDNF on corticostriatal synaptic transmission with field recordings in a male mouse model of HD produced by in vivo treatment with the mitochondrial toxin 3-nitropropionic acid. Here, we show that these neurotrophins elicit an antagonistic or synergistic effect that depends on the activation of the truncated isoform or the stimulation of the full-length isoform of the tropomyosin receptor kinase B (TrkB).

Torres-Cruz, F.M., Mendoza, E., Vivar-Cort’es, I.C., Garc’ia-Sierra, F., and Hern’andez-Echeagaray, E. Do BDNF and NT-4/5 exert synergistic or occlusive effects on corticostriatal transmission in a male mouse model of Huntington’s disease? 06620. 2019 J Neurosci Res.

Concepts Keywords
Acid Branches of biology
BDNF Neuroscience
Corticostriatal Cell signaling
Huntington Developmental neuroscience
Isoform Tyrosine kinase receptors
Kinase Neurochemistry
Mitochondrial Peptide hormones
Neurotrophin Brain-derived neurotrophic factor
Neurotrophins Neurotrophic factors
Occlusive Neurotrophin
Receptor Trk receptor
Striatal
Synaptic Transmission
Synergistic
Toxin
TrkB
Trophic
Tropomyosin

Semantics

Type Source Name
gene UNIPROT NTRK1
gene UNIPROT NTRK2
gene UNIPROT NTF4
gene UNIPROT BDNF

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *