Harnessing T-cell Subtype May Suppress Immune Responses in MS, Study Suggests

Harnessing T-cell Subtype May Suppress Immune Responses in MS, Study Suggests

Publication date: Aug 09, 2019

This post was originally published on this siteThough known mainly for killing tumor and virally infected cells, a T-cell subtype may restrain immune responses and be protective in autoimmune diseases such as multiple sclerosis (MS), according to new research. The involvement of different subtypes of immune T-cells has been shown in MS patients and in the experimental autoimmune encephalomyelitis (EAE) mouse model of the disease. Supporting the findings in mice, analysis in cells isolated from MS patients also showed a marked boost in blood levels of suppressive T-cells and, to a lesser extent, of inflammatory CD4+ T-cells. The team has plans to assess if these suppressor CD8 T-cells also are involved in other autoimmune diseases, including celiac disease. The post Harnessing T-cell Subtype May Suppress Immune Responses in MS, Study Suggests appeared first on Multiple Sclerosis News Today. The post Harnessing T-cell Subtype May Suppress Immune Responses in MS, Study Suggests appeared first on BioNewsFeeds.

Concepts Keywords
Antigen Experimental autoimmune encephalomyelitis
Autoimmune Immune system
Autoimmune Diseases T cells
Autoimmunity Medicine
Blood Immunology
CD4 Branches of biology
CD4+ T Cells Medical specialties
CD8 Autoimmune diseases
CD8+ T Cells Experimental autoimmune uveitis
Celiac Disease Celiac disease
Crowdsourcing MS
Gluten Autoimmunity treatment diseases
Glycoprotein Tumor
HDR T helper cell
Immune Function Myelin oligodendrocyte glycoprotein
Mark Davis Autoimmunity
Mice Regulatory T cell
MOG Protective autoimmunity
Multiple Sclerosis
Myelin
Oligodendrocyte
Pathogen
Peptide
Peptides
PhD
Saligrama
Stanford
Suppressor
T Cell
T Cells
Tumor
Uveitis
Virally Infected

Semantics

Type Source Name
gene UNIPROT DESI1
gene UNIPROT SLC35G1
disease MESH tumor
disease MESH autoimmune diseases
disease MESH multiple sclerosis
disease DOID multiple sclerosis
disease MESH experimental autoimmune encephalomyelitis
disease MESH celiac disease
disease DOID celiac disease
gene UNIPROT RASA1
gene UNIPROT MOG
gene UNIPROT CD4
gene UNIPROT PDC
pathway BSID Release
gene UNIPROT MARK1
gene UNIPROT ABCC5
disease MESH uveitis
disease DOID uveitis
gene UNIPROT TBXT
disease MESH autoimmunity
drug DRUGBANK Nonoxynol-9

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