Alzheimer’s disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview.

Alzheimer’s disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview.

Publication date: Aug 07, 2019

Neuropathological diagnostic criteria of neurodegenerative disorders are based on the presence of specific inclusions in a specific area of brain tissue that correlate with clinical manifestations. Concomitant neurodegenerative disorders correspond to a combination of two (or more) different fully developed diseases in the same patient. Concomitant neurodegenerative pathology represents the presence of definite neurodegeneration and deposits of pathological proteins specific for another disease, which is not, however, fully developed. Very frequent overlaps include Alzheimer’s disease and alpha-synuclein inclusions. Nevertheless, careful neuropathological investigations reveal an increasing frequency of different co-pathologies in examined brains. In Alzheimer’s disease, proteinTDP-43 may co-aggregate, but it is not clear whether this is atypical isolated Alzheimer’s disease or overlap of Alzheimer’s disease with early frontotemporal lobar degeneration. Comorbidities of Alzheimer’s disease and tauopathies are relatively rare. A combination of vascular pathology with primary neurodegeneration (mostly Alzheimer’s disease or dementia with Lewy bodies) is historically called mixed dementia. Overlap of different neuropathologically confirmed neurodegenerations could lead to atypical and unusual clinical presentations and may be responsible for faster disease progression. Several CSF biomarkers have been evaluated for their utility in diagnostic processes in different neurodegenerative dementias; however, evidence regarding their role in neurodegenerative overlaps is still limited.

Matej, R., Tesar, A., and Rusina, R. Alzheimer’s disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview. 21895. 2019 Clin Biochem.

Concepts Keywords
Alzheimer MND
Biomarkers Concomitant neurodegenerative disorders
Brain Pathological specific disease
Comorbidity Diseases
Dementia Cognitive disorders
Frequency Neurological disorders
Lewy Bodies Branches of biology
Neurodegeneration Organ systems
Neurodegenerative Psychiatric diagnosis
Neurodegenerative Disorders Learning disabilities
Neuropathological Aphasias
Pathologies Tauopathy
Pathology Frontotemporal dementia
Frontotemporal lobar degeneration
Primary progressive aphasia
Alpha
CVD

Semantics

Type Source Name
gene UNIPROT TARDBP
disease DOID Synucleinopathy
gene UNIPROT REG1A
gene UNIPROT PSPN
gene UNIPROT BPIFA2
gene UNIPROT PSPH
gene UNIPROT STXBP3
disease MESH PSP
disease DOID progressive supranuclear palsy
disease MESH progressive supranuclear palsy
disease DOID aphasia
disease MESH aphasia
disease DOID tauopathy
drug DRUGBANK Phenylpropanolamine
disease DOID multiple system atrophy
disease MESH multiple system atrophy
gene UNIPROT GGT1
disease DOID motor neuron disease
disease MESH motor neuron disease
disease DOID Creutzfeldt-Jakob disease
disease DOID cerebrovascular disease
disease MESH cerebrovascular disease
disease MESH frontotemporal dementia
gene UNIPROT MAPT
gene UNIPROT CSF2
disease MESH disease progression
disease DOID dementia
disease DOID dementia with Lewy bodies
disease MESH tauopathies
disease DOID frontotemporal lobar degeneration
disease MESH frontotemporal lobar degeneration
gene UNIPROT SNCA
disease MESH neurodegenerative disorders
disease MESH comorbidity
disease MESH dementias

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