Huntington’s Disease: Astrocytes Shift to Fatty Acid Metabolism.

Huntington’s Disease: Astrocytes Shift to Fatty Acid Metabolism.

Publication date: Aug 06, 2019

A recent study by Polyzos et al. (Cell Metab., 2019) shows that astrocytes in a Huntington disease (HD) mouse model switch from glycolysis to fatty acid oxidation (FAO), causing increased superoxide radical anion production and loss of succinate dehydrogenase (SD) activity. Blocking mitochondria reactive oxygen species (ROS) with an antioxidant compound called XJB-5-151 reversed lipofuscin formation and protected the mice.

Van Houten, B. Huntington’s Disease: Astrocytes Shift to Fatty Acid Metabolism. 06623. 2019 Trends Endocrinol Metab.

Concepts Keywords
Anion Beta oxidation
Antioxidant Succinic acid
Astrocytes Reactive oxygen species
FAO Mitochondrion
Fatty Acid Antioxidant
Glycolysis Fatty acids
Huntington Senescence
Lipofuscin Free radicals
Mice Chemistry
Mitochondria Cellular respiration
Oxidation Branches of biology
Oxygen
ROS
Succinate Dehydrogenase
Superoxide Radical

Semantics

Type Source Name
gene UNIPROT ROS1
drug DRUGBANK Succinic acid
pathway BSID Fatty acid oxidation
pathway BSID glycolysis
pathway BSID Glycolysis
disease DOID Huntington disease
disease MESH Huntington disease
pathway BSID Fatty acid metabolism

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